+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Complex influence of the infralimbic cortex on locus coeruleus neuronal activity

Complex influence of the infralimbic cortex on locus coeruleus neuronal activity

Society for Neuroscience Abstracts 26(1-2): Abstract No -657 40

The locus coeruleus (LC) innervates wide areas of the brain and plays a role in learning and memory by releasing norepinephrine (NE). The infralimbic cortex (IL) is also involved in cognition and in integrating peripheral somatic information in the forebrain. Since it is one of only two cortical areas projecting to the LC, we examined the influence of IL cortex on LC neuronal activity. LC activity is recorded in urethane anesthetized rats and a pipette filled with 2% lidocaine is lowered in the IL. A recording electrode is positioned in the IL about 1 mm anterior to the injecting pipette to monitor cortical inhibition by lidocaine. The inactivation of IL leads to a concommittent increase of about 30% in basal firing rate of LC, which would suggest that the IL exerts a tonic inhibitory influence on the LC. Attempts to block the increase by local infusion of a GABA-A antagonist in the LC led, unexpectedly, to a significant decrease in LC firing rate to below baseline. This result indicates that the overall inhibitory effect is, indeed, GABAergic, and reveals a smaller excitatory influence. This points to multiple influences by both direct and indirect pathways. Recent experiments show that one pathway is via the vagus nerve since bilateral vagotomy just prior to the IL inactivation not only blocked the increase in firing in LC but provoked a significant decrease, similar to the effect of the GABA antagonist. These results indicate that the IL exerts a complex tonic influence on LC firing. One pathway appears to be monosynaptic and excitatory. Another is polysynaptic, mediated peripherally, transmitted via the vagus nerve and inhibitory through GABA-A receptors.

(PDF emailed within 1 workday: $29.90)

Accession: 034627662

Download citation: RISBibTeXText

Related references

Tonic inhibitory influence of the infralimbic cortex on spontaneous firing of noradrenergic locus coeruleus neurons. European Journal of Neuroscience 12(Supplement 11): 439, 2000

Changes of the neuronal activity in the visual cortex by stimulation of the locus coeruleus. Izvestiya Akademii Nauk Gruzinskoi SSR Seriya Biologicheskaya 5(2): 126-133, 1979

Dual effect of the locus coeruleus on neuronal activity in the visual cortex. Neurophysiology 25(4): 201-203, 1993

In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol. Synapse 2018, 2018

The effect of electrical stimulation of the locus coeruleus on the neuronal activity of the parietal associative cortex. Neirofiziologiia 22(4): 486-494, 1990

Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex. Neuron 89(1): 221-234, 2016

Effects of applying electrical stimulation to the locus coeruleus on neuronal activity in the parietal association cortex. Neurophysiology 22(4): 359-367, 1990

Locus coeruleus autonomic influence on neuronal activity and behavior. Society for Neuroscience Abstracts 11(2): 829, 1985

The influence of electrical stimulation of the locus coeruleus on the neuronal activity of the dorsal hippocampus. Soobshcheniya Akademii Nauk Gruzinskoi SSR 123(1): 149-152, 1986

Noradrenergic facilitatory influence of locus coeruleus on neuronal activity in the rat lateral geniculate nucleus. Neuroscience Letters (SUPPL 6): S12, 1981

Influence of intracisternal CRF-antagonist and CRF, and colorectal distention of the spontaneous neuronal activity of the nucleus locus coeruleus. Society for Neuroscience Abstracts 21(1-3): 90, 1995

Locus coeruleus neuronal activity and noradrenaline availability in the frontal cortex of rats chronically treated with imipramine: effect of alpha 2-adrenoceptor blockade. Biological Psychiatry 46(6): 766-774, 1999

Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons. Neuroscience 83(1): 63-79, 1998

Influence of electrical stimulation of locus coeruleus on the activity of parietal association cortex neurons. Neirofiziologiya 22(4): 486-494, 1990

Influence of the activity of the locus coeruleus complex on the ventricular extrasystoles induced by hypothalamic stimulation in the rabbit. Acta Physiologica Sinica 36(5): 431-439, 1984