Consumption of no trans margarine decreases human milk and serum conjugated linoleic acid concentrations
Anderson, N.; Mcguire, M.K.; Mcguire, M.A.; Beerman, K.; Dasgupta, N.; Koepp, A.; Falen, L.R.; Griinari, J.M.; Williams, J.
FASEB Journal 16(4): A662
2002
ISSN/ISBN: 0892-6638 Accession: 034642059
Conjugated linoleic acid (CLA) inhibits cancer and alters nutrient partitioning in animals. The most abundant form of CLA in human milk is c9,t11-18:2 (rumenic acid, RA) which is also the major form in the human diet. Maternal RA consumption can affect milk RA, although it is clear that other factors are influential. We studied 12 lactating women in a randomized, Latin-square design with 3 treatments: butter (B), margarine (M) and no trans margarine (NTM). Treatment and washout periods were 5 and 7 d, respectively. Women consumed specially-baked products containing approximately 76 g/d of the appropriate fat and altered their self-selected diets to contain these fats. Milk was collected on d 5 of each treatment period. Dietary treatment did not alter milk fat content but did alter (P<0.005) milk RA (0.43, 0.34 and 0.22% of fatty acids in B, M and NTM periods, respectively) and serum RA (0.32, 0.24 and 0.18% of fatty acids in B, M and NTM periods, respectively). Serum and milk RA concentrations were highly correlated (r=0.575; P<0.0001). The greater concentration of RA in M vs. NTM periods suggests that RA may be formed from other dietary trans fatty acids.