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Determination of flufenamic acid and mefenamic acid in pharmaceutical preparations and biological fluids using flow injection analysis with tris ruthenium chemiluminescence detection


Determination of flufenamic acid and mefenamic acid in pharmaceutical preparations and biological fluids using flow injection analysis with tris ruthenium chemiluminescence detection



Analytica Chimica Acta 416(1): 87-96



ISSN/ISBN: 0003-2670

A novel chemiluminescent method using flow injection has been investigated for the rapid and sensitive determination of flufenamic and mefenamic acids. The method is based on a tris(2,2'-bipyridyl)ruthenium(III) chemiluminescence reaction. Ru(bipy)33+ is chemically generated by mixing two streams containing solutions of tris(2,2'-bipyridyl)ruthenium(II) and acidic cerium(IV) sulphate. After selecting the best operating parameters calibration graphs were obtained over the concentration ranges 0.07-6.0 and 0.05-6.0 mug ml-1 for flufenamic acid and mefenamic acid, respectively. The limits of detection (s/n=3) were 3.6X10-9 M flufenamic acid and 2.1X10-7 M mefenamic acid. The method was successfully applied to the determination of these compounds in pharmaceutical formulations and biological fluids. A proposal for the reaction pathway was given.

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Accession: 034709432

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