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Differential connections of the orbital and medial prefrontal cortex with perirhinal, parahippocampal and entorhinal cortex in the monkey



Differential connections of the orbital and medial prefrontal cortex with perirhinal, parahippocampal and entorhinal cortex in the monkey



Society for Neuroscience Abstracts 27(2): 1691



Previous studies have defined distinct "orbital" and "medial networks" within the orbital and medial prefrontal cortex (OMPFC), which have differential connections with cortical, limbic and subcortical regions. In this study, we examined whether these two networks have distinct connections with perirhinal cortex (areas 35/36), parahippocampal cortex (areas TF/TH) and entorhinal cortex using retrograde and anterograde tracers. Following retrograde tracer injections in areas of the medial network (especially medial areas 10m, 25, 11m, 13a, 14r, 32), retrogradely labeled neurons were found in areas TF/TH and the middle or caudal part of entorhinal cortex (Ei or Ec). In contrast, injections in the orbital network (especially caudal areas Iam, Iapm, Ial, 13b) labeled neurons in areas 35/36 and the rostral part of entorhinal cortex (Er, Eo, Elr). Anterograde tracer injections in the OMPFC labeled fibers from area 25 in medial network that terminate in areas TF/TH and Ei, while labeled projections from the orbital network (areas Iapm, Iam, 13l) were found to terminate in areas 35/36 and the rostral part of entorhinal cortex (Er, Eo, Elr). In addition, ventral and dorsal parts of the temporal pole were previously shown to have selective connections with the orbital and medial networks, respectively. Taken together, these results indicate that the orbital and medial prefrontal networks are part of distinct circuits that involve the temporal pole, perirhial, parahippocampal and entorhinal cortices.

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