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Effect of chlorhexidine/silver sulfadiazine coating on microbial colonization of central venous catheters in a multicenter trial



Effect of chlorhexidine/silver sulfadiazine coating on microbial colonization of central venous catheters in a multicenter trial



Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 439



Background: Central venous catheter (CVC)-related infection (CRI) is a significant medical problem. The purpose of this study was to assess the effect of coating CVCs (external and luminal surfaces) with chlorhexidine/silver sulfadiazine (CH/SS) (ARROWg+ard Blue Plus(R) (2nd generation CH/SS CVC)) on bacterial colonization. Methods: This study was conducted as a prospective, randomized, controlled, double-blind trial involving 9 medical centers in the US. CH/SS coated CVCs or uncoated control CVCs were inserted using standard sterile technique. At the time of discontinuation, the CVCs were aseptically retrieved and cultured using a semi-quantitative roll-plate method and a quantitative sonication technique. CVCs with gtoreq15cfu by roll-plate or gtoreq100 cfu by sonication were regarded as colonized. Results: Major findings are summarized. The organisms most frequently encountered (descending order) were as follows: coagulase-negative staphylococci, S. aureus, Enterococcus sp, Corynebacterium sp and E. coli. Polymicrobic cultures were observed in 25% of colonized CVCs (5 CH/SS, 11 control). Conclusion: CH/SS significantly reduces bacterial colonization of CVCs.

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