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Effect of lafutidine on 13c urea breath test intragastric acidification reduces the frequency of false negative ubt results



Effect of lafutidine on 13c urea breath test intragastric acidification reduces the frequency of false negative ubt results



Digestive Disease Week Abstracts & Itinerary Planner : Abstract No S1230



Background and Aims: Proton pump inhibitor (PPI) is responsible for the false-negative (FN) result in the UBT for detection of H. pylori (HP). However, the assessment of the effect of H2-receptor antagonist (H2RA) on the results of the UBT has shown controversial results, and the study of the effect of lafutidine (LAF, new H2RA) on UBT is still lacking. On the other hand, it has been reported that intragastric acidification reduces the occurrence of FN UBT results in patients taking a PPI. The aims of this study were to determine the effect of LAF on the accuracy of the UBT and to investigate whether a reduction in the intragastric pH, at the time of urea ingestion, would decrease the likelihood of FN UBT results in subjects taking LAF. Subjects and Methods: The study group was consisted of 11 healthy asymptomatic male volunteers with HP infection. Subjects underwent a baseline UBT (UBT-1) followed by taking LAF at a dose of 20 mg/day for 17 days. On day 15, the subjects underwent a repeat of standard UBT (UBT-2). On day 17, the subjects underwent a modified UBT (UBT-3), which included consuming 200 ml of 0.1 N citrate solution 30 min before and at the time of 13C-urea administration. Breath samples were collected at 20 min after UBT. The cut-off value of 13C-UBT for the diagnosis of HP infection was 2.5 delta per mil (J Gastroenterology 1998; 33: 6-13). Results: LAF caused a significant decrease in UBT value (delta per mil) when compared between UBT-1(29.4 +- 18.9) and UBT-2 (17.2 +- 10.8) values (p < 0.05). LAF caused only one FN. UBT value of UBT-3 (42.2 +- 22.3) was greater than that of UBT-2 (p < 0.05). UBT-3 did not cause FN. Conclusion: LAF affects the results of the UBT. Giving citrate before and at the time of 13C-urea intake increases the UBT value and decreases the FN in subjects under taking LAF. These observations suggest that it is possible to design a UBT protocol that will increase the accuracy of UBT in the face of acid suppression therapy.

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Accession: 034798878

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