+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of cytokines and CD4+CD25+ subsets on CD4+CD25- cells in the generation and renewal of regulatory T cells



Effects of cytokines and CD4+CD25+ subsets on CD4+CD25- cells in the generation and renewal of regulatory T cells



FASEB Journal 18(4-5): Abst 779 1



Thymus-derived, natural CD4+CD25+ regulatory T cells can educate peripheral CD4+CD25- cells to develop suppressive activity by poorly understood mechanisms. TGF-β has IL-2 dependent co-stimulatory effects on alloactivated naIve, human CD4+ T cells and induces them ex-vivo to become potent contact-dependent, cytokine-independent suppressor cells. Here we report that the rare naIve CD4+CD25+ cells are the targets of the co-stimulatory effects of IL-2 and TGF-β. These cells do not divide, but, instead, greatly increase the numbers of CD4+CD25- cells that become CD25+ cytokine-independent suppressor cells. These CD4+CD25+ regulatory cells, in turn, can induce other alloactivated CD4+ CD25- cells to become potent suppressor cells by mechanisms that, surprisingly, requires both cell contact and TGF-β and IL-10. The suppressive effects of these secondary CD4+CD25+ cells depend upon TGF-β and IL-10. We suggest that the long-term effects of adoptively transferred natural-like CD4+CD25+ regulatory cells induced ex-vivo is due to their ability to generate new cytokine-producing CD4+ regulatory T cells in vivo.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 034817773

Download citation: RISBibTeXText


Related references

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. International Immunology 20(3): 421-431, 2008

Expression of the integrin aEb7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America 99(20): 031-6, 2002

Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America 99(20): 13031-6, 2002

CD25-positive cells during pregnancy: Differential profile of cytokines and soluble MHC antigens produced by CD25+CD4+ and CD25+CD8+ cells. Journal of Reproductive Immunology 71(2): 173-0, 2006

Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cells. Journal of Immunology 178(7): 4051-4061, 2007

De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proceedings of the National Academy of Sciences of the United States of America 102(11): 4103-4108, 2005

The IL-4 Receptor a-Chain-Binding Cytokines, IL-4 and IL-13, Induce Forkhead Box P3-Expressing CD25+CD4+ Regulatory T Cells from CD25-CD4+ Precursors. Journal of Immunology 175(9): 07-16, 2005

The IL-4RALPHA chain-binding cytokines, IL-4 and IL-13, induce FOXP3 expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. 2006

The Il-4 Receptor -Chain-Binding Cytokines, Il-4 and Il-13, Induce Forkhead Box P3-Expressing Cd25+Cd4+ Regulatory T Cells from Cd25-Cd4+ Precursors. The Journal of Immunology 175(9): 6107-6116, 2005

The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. Journal of Immunology 175(9): 6107-6116, 2005

Effect of CD4+CD25+ and CD4+CD25- T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro. Journal of Immunology 176(2): 984-990, 2006

Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells. Journal of Immunology 173(1): 267-274, 2004

Il-4 Has Tolerogenic And Allogenic Effects: It Activates Cd4+Cd25+ T Cells To Induce Specific Transplant Tolerance And Promotes Rejection, Effecting Cd4+Cd25-T Cells To Express Cd25 But Not Foxp3. Transplantation 86(Suppl.): 513-514, 2008

In vitro effects of meloxicam on the number, Foxp3 expression, production of selected cytokines, and apoptosis of bovine CD25+CD4+ and CD25-CD4+ cells. Journal of Veterinary Science 14(2): 125-134, 2014

Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Letters 253(1): 144-153, 2007