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Evaluation to detect gram-negative bacterial resistance with garenoxacin, gemifloxacin, and ertapenem in MicroScan Dried Overnight panels



Evaluation to detect gram-negative bacterial resistance with garenoxacin, gemifloxacin, and ertapenem in MicroScan Dried Overnight panels



Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 43: 170



Background: The MicroScan System provides automated, semi-automated or manual antimicrobial susceptibility testing for the clinical laboratory. Garenoxacin, gemifloxacin, and ertapenem are three new antimicrobials being developed for MicroScan Dried Overnight Gram-Negative panels. Methods: A total of 300 gram-negative isolates, including both Enterobacteriaceae and non-Enterobacteriaceae, were tested for MIC determination using MicroScan Dried panels (Test) and NCCLS broth microdilution reference panels. These organisms included a variety of different resistance patterns and MICs. Test and reference panels were prepared using the same inoculum. Results: Essential agreement (+/- 1 doubling dilution) between the MicroScan panel and the reference panel was 97.4% (294/302) for garenoxacin, 96.0% (290/302) for gemifloxacin, and 92.7% (279/301) for ertapenem. Categorical agreement was 95.3% for garenoxacin, 95.7% for gemifloxacin, and 96.0% for ertapenem. There were no major or very major errors with any antimicrobial. Conclusion: This study showed that the performance of the MicroScan Dried Overnight Gram-Negative panels for garenoxacin, gemifloxacin, and ertapenem gave excellent correlation when compared to an NCCLS broth dilution reference method and can provide accurate detection of resistance to these three antimicrobials.

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Accession: 034887010

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