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Factors influencing the timing of trace conditioned eyelid responses Conditioned stimulus offset and the cerebellum



Factors influencing the timing of trace conditioned eyelid responses Conditioned stimulus offset and the cerebellum



Society for Neuroscience Abstracts 27(2): 1687



Trace conditioning procedures can be exploited in unique ways that permit analyses of how various properties of the conditioned stimulus (CS) influence the timing of conditioned eyelid responses. Here, we varied CS duration to determine whether CS onset, offset or both influence the timing of trace conditioned responses before and after reversible pharmacological lesion of the cerebellar cortex. Two groups of rabbits, differing with respect to CS duration (100 vs 500ms), were trained to a standard trace protocol with a 500ms trace interval. After 10 training sessions, onset latencies to 100 and 500ms CS probe trials were measured followed by an infusion of picrotoxin (PTX) into the interpositus nucleus and additional 100 and 500ms CS probe trials. Next, the rabbits were trained to a standard delay protocol, and subsequently infused with PTX. The data are summarized as follows: 1) onset latencies differed for 100 and 500ms probe trials within, but not between groups (mean onset latencies were 430 vs 709ms for the 100ms group and 475 vs 712ms for the 500ms group), indicating that the timing of the eyelid responses was time-locked to CS offset, 2) PTX infusions yielded fixed short-latency responses for each group and probe trial, and 3) trace and delay conditioning PTX tests did not reveal any instances where short-latency responses were observed for one, but not the other protocol. These data suggest that CS offset controls the timing of trace conditioned eyelid responses. Moreover, it appears that the cerebellar cortex is involved in transforming information about CS offset into appropriately timed conditioned eyelid responses.

Accession: 034920483

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