+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Genomics via optical mapping with ordered restriction maps



Genomics via optical mapping with ordered restriction maps



Official Gazette of the United States Patent and Trademark Office Patents 1254(4)



A method of producing high-resolution, high-accuracy ordered restriction maps based on data created from the images of populations of individual DNA molecules (clones) digested by restriction enzymes. Detailed modeling and a statistical algorithm, along with an interactive algorithm based on dynamic programming and a heuristic method employing branch-and-bound procedures, are used to find the most likely true restriction map, based on experimental data.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 034990322

Download citation: RISBibTeXText


Related references

Genomics via optical mapping ordered restriction maps. Official Gazette of the United States Patent and Trademark Office Patents 1242(3), 2001

Genomics via optical mapping. II: Ordered restriction maps. Journal of Computational Biology 4(2): 91-118, 1997

Ordered restriction maps of Saccharomyces cerevisiae chromosomes constructed by optical mapping. Science 262(5130): 110-114, 1993

Ordered restriction endonuclease maps of yeast artificial chromosomes created by optical mapping on surfaces. Proceedings of the National Academy of Sciences of the United States of America 92(11): 5164-5168, 1995

High-resolution restriction maps of bacterial artificial chromosomes constructed by optical mapping. Proceedings Of The National Academy Of Sciences Of The United States Of America. 95(7): 3390-3395, Ch 31, 1998

An algorithm for assembly of ordered restriction maps from single DNA molecules. Proceedings of the National Academy of Sciences of the United States of America 103(43): 15770, 2006

Efficient and scalable scaffolding using optical restriction maps. Bmc Genomics 15(Suppl. 5): S5, 2014

Is It Ordered Correctly? Validating Genome Assemblies by Optical Mapping. Plant Cell 30(1): 7-14, 2018

Optical mapping in plant comparative genomics. Gigascience 4: 3, 2015

Genomics via optical mapping. III: Contiging genomic DNA. Proceedings. International Conference on Intelligent Systems for Molecular Biology 1999: 18-27, 1999

Optical mapping approaches to molecular genomics. Current Opinion in Biotechnology 8(1): 70-74, 1997

Cosmid restriction maps generated using pDUAL clones in drop-out mapping. Abstracts of the General Meeting of the American Society for Microbiology 95: 526, 1995

Scaffolding and validation of bacterial genome assemblies using optical restriction maps. Bioinformatics 24(10): 1229-1235, 2008

A strategy for constructing high-resolution genetic maps of the human genome: a genetic map of chromosome 17p, ordered with meiotic breakpoint-mapping panels. American Journal of Human Genetics 56(2): 484-499, 1995

Multiple-complete-digest restriction fragment mapping: Generating sequence-ready maps for large-scale DNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 94(10): 5225-5230, 1997