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Handwriting tremor anisotropy in patients with essential tremor and parkinsons disease



Handwriting tremor anisotropy in patients with essential tremor and parkinsons disease



Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 666 5



Handwriting tremor is found in patients with essential tremor (ET) and Parkinsons disease (PD). To exam tremor anisotropy a characterization of how focused a tremor is aligned along its axis we developed a handwriting spiral analysis technique which can quantitatively test the tremor anisotropy. Fourteen clinically established ET patients with writing tremors (aged 66-78 years, 72.15.3, mean SD, 218 trials) are compared with fourteen patients clinically diagnosed with definite PD (aged 43-79 years, 55.312.3, mean SD, 245 trials) who also exhibit writing tremor were studied. Subjects executed a serious of visually guided written spirals of both hands on a digitized table (sampling rate 70 Hz). Quantitative anisotropy analysis is calculated from the tremor spectra obtained from fast Fourier transforms of the handwritten spiral cumulatively projected over 360. It is measured on a scale of 0 to 1 where anisotropy of 1 indicates that the recorded tremor strongly aligns in a single direction and 0 indicates that the tremor uniformly distributes in all directions. Results from this study show that the mean handwriting spiral tremor anisotropy in PD (0.900.05) is significantly lower (p<0.05, t-test) than ET (0.970.02), regardless of the amplitude of the tremor or the hand tested. These findings show that ET and PD can be separated on the basis of tremor anisotropy. Furthermore, these results imply that ET and PD tremors likely develop through different neuronal generators and or other mechanisms and therefore would likely require different medical or surgical treatment approaches.

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Accession: 035015743

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