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Hepatocyte nuclear factor-6 is a novel transcriptional activator in cholangiocytes and is involved in the bile duct proliferative response to obstructive jaundice


, : Hepatocyte nuclear factor-6 is a novel transcriptional activator in cholangiocytes and is involved in the bile duct proliferative response to obstructive jaundice. Pediatrics 104(3 PART 3): 788, Sept


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Lalisang, T.J.M.; Sjamsuhidajat, R.; Siregar, N.C.; Taher, A., 2011: Profile of hepatocyte apoptosis and bile lakes before and after bile duct decompression in severe obstructive jaundice patients. Excessive hepatocyte apoptosis and bile lakes in severe obstructive jaundice might impair liver functions. Although decompression of the bile duct has been reported to improve liver functions in animal studies, the mechanism of obstruction differs...

Kaler, B.; Karram, T.; Morgan, W.A.; Bach, P.H.; Yousef, I.M.; Bomzon, A., 2004: Are bile acids involved in the renal dysfunction of obstructive jaundice? An experimental study in bile duct ligated rats. Background. Surgery on patients with obstructive jaundice is associated with a significant risk of postoperative renal failure. Bile acids are implicated as nephrotoxins because they accumulate in the plasma and the kidney becomes their only excre...

Alpini, G.; Glaser, S.S.; Ueno, Y.; Pham, L.; Podila, P.V.; Caligiuri, A.; LeSage, G.; LaRusso, N.F., 1998: Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. We previously introduced the concept that intrahepatic bile duct epithelial cells, or cholangiocytes, are functionally heterogeneous. This concept is based on the observation that secretin receptor (SR) gene expression and secretin-induced cAMP sy...

Zipprich B.; Mueller B.; Martin P., 1991: Bile duct endoprostheses with special regard to long time observations of patients with obstructive jaundice caused by bile duct stones. Zeitschrift fuer Gastroenterologie 29(SUPPL 2): 39-41

Samadani, U.; Costa, R.H., 1996: The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. The hepatocyte nuclear factor 3(alpha) (HNF-3(alpha)), -3(beta), and -3(gamma) proteins share homology in the winged-helix/fork head DNA binding domain and mediate hepatocyte-enriched transcription of numerous genes whose expression is necessary f...

Younes, R.N.; Vydelingum, N.A.; Derooij, P.; Scognamiglio, F.; Andrade, L.; Posner, M.C.; Brennan, M.F., 1991: Metabolic alterations in obstructive jaundice: effect of duration of jaundice and bile-duct decompression. We examined the effect of prolonged bile duct obstruction, and subsequent biliary decompression, on biochemical and metabolic parameters, using a reversible jaundice model in male Fischer 344 rats. The animals were studied after biliary obstructio...

Shibata, T.; Sato, T.; Kondo, H.; Ootani, I.; Suzuki, H.; Kawada, S., 1990: Two cases of obstructive jaundice due to extrahepatic carcinoma of the bile duct with marked response to daily oral administration of etoposide. Two cases of obstructive jaundice due to cancer of extrahepatic bile duct were treated with a combination chemotherapy combined with etoposide. The first case was a 81-year-old male and the second case was a 62-year-old female who introduced to th...

Green, V.J.; Kokkotou, E.; Ladias, J.A., 1998: Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4. The nuclear receptor hepatocyte nuclear factor 4 (HNF-4) is an important regulator of several genes involved in diverse metabolic and developmental pathways. Mutations in the HNF-4A gene are responsible for the maturity-onset diabetes of the young...

Ban, N.; Yamada, Y.; Someya, Y.; Miyawaki, K.; Ihara, Y.; Hosokawa, M.; Toyokuni, S.; Tsuda, K.; Seino, Y., 2002: Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Mutations in the hepatocyte nuclear factor (HNF)-1alpha gene have been linked to subtype 3 of maturity-onset diabetes of the young (MODY), a disease characterized by a primary defect in insulin secretion. Here we show that the human GLUT2 gene is...

Schmorell, H., 1950: Obstructive jaundice from stone in the common bile duct in aplasia of the gallbladder; multiple and papillary cholelithiasis of the common bile duct. Zentralblatt für Chirurgie 75(24/A): 1721-1722