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Human centromere activation and inactivation


, : Human centromere activation and inactivation. Molecular Biology of the Cell 11(Supplement): 96a, Dec


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Han, Y.; Zhang, Z.; Liu, C.; Liu, J.; Huang, S.; Jiang, J.; Jin, W., 2009: Centromere repositioning in cucurbit species: implication of the genomic impact from centromere activation and inactivation. The centromere of an eukaryotic chromosome can move to a new position during evolution, which may result in a major alteration of the chromosome morphology and karyotype. This centromere repositioning phenomenon has been extensively documented in...

Ngan, V.K.; Clarke, L., 1997: The centromere enhancer mediates centromere activation in Schizosaccharomyces pombe. The centromere enhancer is a functionally important DNA region within the Schizosaccharomyces pombe centromeric K-type repeat. We have previously shown that addition of the enhancer and cen2 centromeric central core to a circular minichromosome is...

Voullaire, L.E.; Slater, H.R.; Petrovic, V.; Choo, K.H., 1993: A functional marker centromere with no detectable alpha-satellite, satellite III, or CENP-B protein: activation of a latent centromere?. We report the investigation of an unusual human supernumerary marker chromosome 10 designated "mar del(10)." This marker is present together with two other marker chromosomes in the karyotype of a boy with mild developmental delay. It ha...

Song, K.; Tomkiel, J.E., 1997: Mutational analysis of human centromere protein C reveals two independent centromere localization domains. Molecular Biology of the Cell 8(SUPPL ): 267A, Nov

Song, K.; Gronemeyer, B.; Lu, W.; Eugster, E.; Tomkiel, J.E., 2002: Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C). Human centromere protein C (CENP-C) is an essential component of the inner kinetochore plate. A central region of CENP-C can bind DNA in vitro and is sufficient for targeting the protein to centromeres in vivo, raising the possibility that this do...

Brinkley, B.R.; He, D., 1996: Repeat subunit structure of the centromere-kinetochore complex of human chromosomes CENPs and alpha-satellite DNA localization in centromere domains. Molecular Biology of the Cell 7(SUPPL ): 5A

Hadlaczky, G.; Praznovszky, T.; Rasko, I.; Kereso, J., 1989: Centromere proteins. I. Mitosis specific centromere antigen recognized by anti-centromere autoantibodies. Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr = 59,000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mi...

Daniel, Art, 2002: Distortion of female meiotic segregation and reduced male fertility in human Robertsonian translocations Consistent with the centromere model of co-evolving centromere DNA/centromeric histone. American Journal of Medical Genetics 111(4): 450-452, September 1

Daniel, A., 2002: Distortion of female meiotic segregation and reduced male fertility in human Robertsonian translocations: consistent with the centromere model of co-evolving centromere DNA/centromeric histone (CENP-A). American Journal of Medical Genetics 111(4): 450-452

Therman E.; Trunca C.; Kuhn E.M.; Sarto G.E., 1986: Dicentric chromosomes and the inactivation of the centromere. The origin and behavior of human dicentric chromosomes are reviewed. Most dicentrics between two non-homologous or two homologous chromosomes (isodicentrics), which are permanent members of a chromosome complement, probably originate from segregat...