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In vitro sensitivity of Leishmania braziliensis and Leishmania amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B


In vitro sensitivity of Leishmania braziliensis and Leishmania amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B



Tropical Medicine And International Health: 1, 68-76



Resistance of Leishmania parasites to specific chemotherapy has become a well-documented problem in the Indian subcontinent in recent years but only a few studies have focused on the susceptibility of American Leishmania isolates. Our susceptibility assays to meglumine antimoniate were performed against intracellular amastigotes after standardizing an in vitro model of macrophage infection appropriate for Leishmania (Viannia) braziliensis isolates.

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