+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Incidence and risk factors of non AIDS-defining as compared with AIDS-defining infections and cancers in a cohort of HIV-infected patients initiating a protease inhibitor -containing regimen

Incidence and risk factors of non AIDS-defining as compared with AIDS-defining infections and cancers in a cohort of HIV-infected patients initiating a protease inhibitor -containing regimen

Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 320

Background: As opposed to progression to AIDS and death, the incidence and risk factors of non AIDS-related infections and cancers have rarely been studied in the HAART era. Methods: APROCO cohort enrolled 1,281 pts at the initiation of a PI-containing regimen. We analyzed the incidence of AIDS-defining (ADIC) and non AIDS-defining (non-ADIC) infections and cancers occurring after the first 4 mo of HAART and studied the risk factors for each event using multivariate Cox models including CD4+ cell counts and plasma HIV RNA as time-dependent variables. Results: At baseline, 20% of pts had AIDS and 35% had CD4<200/mm3. Median follow-up was 24 mo. Incidence of ADIC (n=43; 2.3/100 pts-yrs) and non-ADIC (n=40; 2.1/100 pts-yrs) was similar. The most frequent non-ADIC were bacterial pneumonia (n=21), septicemia (n=7), cancer (n=4) and Hodgkin's disease (n=3). Non-ADIC were associated with age (HR=1.6/10 yrs older, p<0.01), most recent CD4<100/mm3 (HR=3.4; p=0.01) and HIV RNA>10,000 c/ml (HR=3.7; p<0.001). ADIC were less frequent in pts with higher level of education (hazard ratio (HR)=0.3; p=0.02) and were associated with previous AIDS (HR=3.6; p<0.0001), most recent CD4<100 (HR=8.7; p<0.0001) or between 100 and 200/mm3 (HR=3.1; p=0.01) and HIV RNA>50,000 c/ml (HR=6.8; p<0.0001). Naivete, type of HAART and infection with HCV or HBV were not associated with occurrence of ADIC or non-ADIC. Conclusion: Infections and cancers, whatever AIDS-related or not, are rare after the first 4 months of HAART and associated with severe immunologic and/or viral failure. Pts with high level of education may be at lower risk of progression.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 035113685

Download citation: RISBibTeXText

Related references

Incidence of AIDS-defining cancers and virus-related and non-virus-related non-AIDS-defining cancers among HIV-infected patients compared with the general population in a large health district of Northern Italy, 1999-2009. HIV Medicine 14(8): 481-490, 2014

Association of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study. Annals of Internal Medicine 169(2): 87-96, 2018

Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: a systematic review. Journal of Infection and Public Health 8(1): 1-10, 2015

Trends in the incidence of AIDS-defining and non-AIDS-defining cancers in people living with AIDS: a population-based study from São Paulo, Brazil. International Journal of Std and Aids 28(12): 1190-1198, 2017

Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals. Cancer 104(7): 1505-1511, 2005

Incidence and risk factors of AIDS-defining cancers in a cohort of HIV-positive adults: Importance of the definition of incident cases. Enfermedades Infecciosas Y Microbiologia Clinica 31(5): 304-312, 2013

Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients. Journal of Clinical Oncology 21(18): 3447-3453, 2003

Increased risk of non-AIDS-defining cancers in Asian HIV-infected patients: a long-term cohort study. Bmc Cancer 18(1): 1066, 2018

Use of statins and risk of AIDS-defining and non-AIDS-defining malignancies among HIV-1 infected patients on antiretroviral therapy. Aids 28(16): 2407-2415, 2014

Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United States. Aids Patient Care and Stds 24(5): 279-286, 2010

Risk of AIDS-defining cancers among HIV-1-infected patients in France between 1992 and 2009: results from the FHDH-ANRS CO4 cohort. Clinical Infectious Diseases 57(11): 1638-1647, 2013

Short Communication: HIV RNA Levels Predict AIDS-Defining and Non-AIDS-Defining Cancers After Antiretroviral Therapy Initiation Among HIV-Infected Adults. Aids Research and Human Retroviruses 31(5): 514-518, 2015

Risk of non-AIDS-defining cancers among HIV-1-infected individuals in France between 1997 and 2009: results from a French cohort. Aids 28(14): 2109-2118, 2014

A case-control study of non-AIDS-defining cancers in a prospective cohort of HIV-infected patients. Medicina Clinica 150(8): 291-296, 2018

Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort. Plos one 13(12): E0208657, 2018