+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of noninactivating Na channels of mammalian optic nerve as a means of preventing optic nerve degeneration associated with glaucoma



Inhibition of noninactivating Na channels of mammalian optic nerve as a means of preventing optic nerve degeneration associated with glaucoma



Official Gazette of the United States Patent and Trademark Office Patents 1260(3)



A method and composition for altering a plausible sequence of pathological events in retinal ganglion cells associated with glaucoma, the sequence including membrane depolarization, influx of millimolar amounts of Na+ via non-inactivating Na+ chanels, and the lethal elevation of cell Ca2+ due to reversal of the Na+ /Ca2+ exchanger. The method includes blocking, by administration of a selected composition, of associated, non-inactivating Na+ channels in retinal ganglion cells in order to limit Na+ /Ca+ exchange in the retinal ganglion cells and prevent buildup of the Ca2+ level in the retinal ganglion cells to a lethal level. The results in a method of preventing retinal ganglion cell death, associated with glaucoma, by administering to the optic nerve of a mammal, a compound which blocks the non-inactivating sodium ion channels of the optic nerve. Alternately, said invention relates to a method of preventing optic retinal ganglion cell death in a human by administering to the retinal ganglion cells of said human a compound which blocks the non-inactivating sodium ion channel of the retinal ganglion cells.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 035143089

Download citation: RISBibTeXText


Related references

Optic nerve head deformation in glaucoma: the temporal relationship between optic nerve head surface depression and retinal nerve fiber layer thinning. Ophthalmology 121(12): 2362-2370, 2014

Autoantibodies in patients with glaucoma a comparison of igg serum antibodies against retinal, optic nerve, and optic nerve head antigen. ARVO Annual Meeting Abstract Search and Program Planner : Abstract No 4358, 2003

Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens. Graefe's Archive for Clinical and Experimental Ophthalmology 243(8): 817-823, 2005

Comparison of the Deep Optic Nerve Structures in Superior Segmental Optic Nerve Hypoplasia and Primary Open-Angle Glaucoma. Journal of Glaucoma 25(8): 648-656, 2016

The healing optic nerve in glaucoma: transforming growth factor beta and optic nerve head remodelling. British Journal of Ophthalmology 83(2): 132-133, 1999

Visual field loss associated with optic nerve tilting or congenitally enlarged optic nerve cups a variant of optic nerve hypoplasia?. ARVO Annual Meeting Abstract Search and Program Planner : Abstract No 617, 2003

Evaluation of the optic nerve and scleral-choroidal-retinal layer with ultrasound elastography in glaucoma and physiological optic nerve head cupping. Medical Ultrasonography 1(1): 76-79, 2018

Ischemic events after orbital optic nerve amputation for removal of optic nerve glioma and optic nerve sheath meningioma. IOVS 41(4): S647, 2000

Angioarchitecture of the optic nerve 2. blood supply to the chiasma and the optic nerve and microcirculation within the optic nerve in guinea pigs. Kumamoto Medical Journal 38(1): 9-18, 1985

Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc. British Journal of Ophthalmology 53(11): 721-748, 1969

The optic syrinx cavernous degeneration of the optic nerve demonstrated by lopamidol optic neurography. Ajnr 8(2): 349-352, 1987

Pallor of the optic papilla--an early sign of glaucoma. A clinical controlled study of optic disk pallor and papillar cupping in glaucoma simplex, ocular hypertension and normal eyes with the optic nerve head analyzer. Klinische Monatsblatter für Augenheilkunde 194(6): 433-436, 1989

Quantitative 3-T diffusion tensor imaging in detecting optic nerve degeneration in patients with glaucoma: association with retinal nerve fiber layer thickness and clinical severity. Neuroradiology 55(4): 493-498, 2013

Glaucoma and optic nerve drusen: Limitations of optic nerve head OCT. Journal Francais d'Ophtalmologie 40(7): 542-546, 2017

Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders. Documenta Ophthalmologica. Advances in Ophthalmology 59(3): 217-246, 1985