+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intrinsic primary afferent neurons and nerve circuits within the intestine

Intrinsic primary afferent neurons and nerve circuits within the intestine

Progress in Neurobiology 72(2): 143-164

Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different from all other peripheral neurons. The IPANs are transducers of physiological stimuli, including movement of the villi or distortion of the mucosa, contraction of intestinal muscle and changes in the chemistry of the contents of the gut lumen. They are the first neurons in intrinsic reflexes that influence the patterns of motility, secretion of fluid across the mucosal epithelium and local blood flow in the small and large intestines. In the guinea pig small intestine, where they have been characterized in detail, IPANs have Dogiel type II morphology, that is they are large round or oval neurons with multiple processes, some of which end close to the luminal surface of the intestine, and some of which form synapses with enteric interneurons, motor neurons and with other IPANs. The IPANs have well-defined ionic currents through which their excitability, and their functions in enteric nerve circuits, is determined. These include voltage-gated Na(+) and Ca(2+) currents, a long lasting calcium-activated K(+) current, and a hyperpolarization-activated cationic current. The IPANs exhibit long-term changes in their states of excitation that can be induced by extended periods of low frequency activity in synaptic inputs and by inflammatory mediators, either applied directly or released during an inflammatory challenge. The IPANs may be involved in pathological changes in enteric function following inflammation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 035173344

Download citation: RISBibTeXText

PMID: 15063530

DOI: 10.1016/j.pneurobio.2003.12.004

Related references

Primary afferent neurons intrinsic to the guinea-pig intestine, like primary afferent neurons of spinal and cranial sensory ganglia, bind the lectin, IB4. Cell and Tissue Research 321(2): 151-157, 2005

Intrinsic primary afferent neurons of the intestine. Progress in Neurobiology 54(1): 1-18, 1998

Immunohistochemical localisation of cholinergic markers in putative intrinsic primary afferent neurons of the guinea-pig small intestine. Cell & Tissue Research. 29(1): 35-43,., 1998

The immunohistochemical localization of cholinergic markers in putative intrinsic primary afferent neurons of the guinea-pig small intestine. Society for Neuroscience Abstracts 24(1-2): 1335, 1998

Evidence for protein kinase involvement in long-term postsynaptic excitation of intrinsic primary afferent neurons in the intestine. Autonomic Neuroscience 115(1-2): 1-6, 2004

Inputs from intrinsic primary afferent neurons to nitric oxide synthase-immunoreactive neurons in the myenteric plexus of guinea pig ileum. Cell & Tissue Research 299(1): 1-8, 2000

P2X receptors mediate synaptic transmission from descending interneurons, but not from intrinsic primary afferent neurons, to inhibitory motor neurons in the guinea-pig ileum. Gastroenterology 118(4 Suppl 2 Part 1): AGA A877, April, 2000

Intrinsic properties of vestibular primary afferent neurons in culture. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 702 7, 2003

Electrical mapping of the projections of intrinsic primary afferent neurones to the mucosa of the guinea-pig small intestine. Neurogastroenterology and Motility 10(6): 533-541, 1999

Differential inhibitory control of semicircular canal nerve afferent-evoked inputs in second-order vestibular neurons by glycinergic and GABAergic circuits. Journal of Neurophysiology 99(4): 1758-1769, 2008

Choline acetyltransferase immunoreactivity of putative intrinsic primary afferent neurons in the rat ileum. Cell & Tissue Research 297(2): 241-248, 1999

Intrinsic neurons in the duck choroid receive sympathetic and trigeminal primary afferent input. IOVS 40(4): S451, March 15, 1999

5-HT activates intestinal intrinsic primary afferent neurons via 5-HT3 receptors in the guinea pig myenteric plexus. Society for Neuroscience Abstracts 24(1-2): 879, 1998

Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons. Journal of Neuroscience 15(11): 7633-7643, 1995

Identification of enteric primary afferent neurons in the guinea-pig small intestine. Gastroenterology 122(4 Suppl 1): A 91-A 92, April, 2002