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Is the IgE-induced upregulation of FcepsilonRI on basophils a result of IgE stabilizing FcepsilonRI against proteolytic breakdown?

, : Is the IgE-induced upregulation of FcepsilonRI on basophils a result of IgE stabilizing FcepsilonRI against proteolytic breakdown?. Journal of Allergy & Clinical Immunology 109(1 Supplement): S249, January

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MacGlashan, D.; Lichtenstein, L.M.; McKenzie-White, J.; Chichester, K.; Henry, A.J.; Sutton, B.J.; Gould, H.J., 1999: Upregulation of FcepsilonRI on human basophils by IgE antibody is mediated by interaction of IgE with FcepsilonRI. Background: IgE is now known to upregulate the expression of FcepsilonRI on human basophils. It is not known which receptor on basophils mediates this process of upregulation. Objective: We sought to determine whether galectin-3, FcepsilonRII (CD2...

Yamagishi, S.; Pawankar, R.; Takizawa, R.; Nonaka, M.; Yagi, T., 2003: Nasal epithelial cells express the FcepsilonRI IL-4 induced upregulation of the FcepsilonRI and IL-6 production. Journal of Allergy & Clinical Immunology 111(2 Abstract Supplement): S347, February

Macglashan, D.W.Jr; Mckenzie, J.; Lavens Phillips, S.E.; Henry, A.J.; Sutton, B.J.; Gould, H.J., 1998: IgE interacts with FcepsilonRI to induce FcepsilonRi up-regulation on human basophils. FASEB Journal 12(5): A1061, March 20

Kubo, S.; Matsuoka, K.; Taya, C.; Kitamura, F.; Takai, T.; Yonekawa, H.; Karasuyama, H., 2001: Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface. It has been shown that IgE binding to FcepsilonRI on mast cells results in increased FcepsilonRI expression, which in turn enhances IgE-dependent chemical mediator release from mast cells. Therefore, prevention of the IgE-mediated FcepsilonRI up-r...

Nunomura, S.; Gon, Y.; Yoshimaru, T.; Kashiwakura, J.; Kawakami, T.; Ra, C., 2010: FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors. Simultaneous stimulation with antigen and adenosine in mast cells induces a synergistic degranulation response at a low antigen dose that is insufficient to cause secretion by itself. This kind of stimulation is thought to be relevant to the immed...

Suzukawa, M.; Hirai, K.; Iikura, M.; Nagase, H.; Komiya, A.; Yoshimura-Uchiyama, C.; Yamada, H.; Ra, C.; Ohta, K.; Yamamoto, K.; Yamaguchi, M., 2005: IgE- and FcepsilonRI-mediated migration of human basophils. Local accumulation of basophils at inflammatory sites is observed in experimental antigen challenge and in allergic diseases. It is not fully known what factor(s) regulates local basophil influx in tissues, and it has not been determined whether a...

Vilarino, N.; Macglashan, D.W., 2003: Downregulation of early FcepsilonRI signaling by the actin cytoskeleton in basophils. FASEB Journal 17(7): C13, April 14

MacGlashan, D.W., 2007: Endocytosis, recycling, and degradation of unoccupied FcepsilonRI in human basophils. Previous studies about basophils and mast cells identified the ability of IgE to up-regulate Fc epsilon RI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface,...

Jensen, B.M.J.; Thygesen, C.T.; Hansen, J.B.H.; Dissing, S.D.; Gerwien, J.G.; Kampen, G.T.K.; Skov, P.S.S.; Poulsen, L.K.P., 2001: The IgE induced upregulation of the high affinity IgE receptor does not involve tyrosine phosphorylation, increase in intracellular Ca2+ or changes in the steady state level of the FcepsilonRI mRNA. Allergy (Copenhagen) 56(Supplement 68): 119

Kepley, C.; Foutz, T.; Wilson, B.; Oliver, J., 1998: Negative regulation of FcepsilonRI-mediated human basophils degranulation by CD32. FASEB Journal 12(5): A1061, March 20