+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Matrix metalloproteinases in tumor invasion and metastasis



Matrix metalloproteinases in tumor invasion and metastasis



Seminars in Cancer Biology 10(6): 415-433



Extensive work on the mechanisms of tumor invasion and metastasis has identified matrix metalloproteinases (MMPs) as key players in the events that underlie tumor dissemination. Studies using natural and synthetic MMP inhibitors, as well as tumor cells transfected with cDNAs encoding the MMPs characterized thus far have provided compelling evidence that MMP activity can induce or enhance tumor survival, invasion and metastasis. Because of the ability of MMPs to degrade extracellular matrix (ECM) proteins, the principal mechanism whereby MMPs promote tumor development has been thought to be the proteolytic breakdown of tissue barriers to invasion and the associated facilitation of circulating tumor cell extravasation. However, recent evidence stemming from the use of novel experimental approaches indicates that MMPs do not play a major role in the process of extravasation itself. Rather, they appear to promote intravasation (the process of penetrating the circulation following invasion of blood vessels) and regulate the relationship between tumor cells and host tissue stroma subsequent to extravasation. In addition, the discoveries that a growing number of proteolytically active MMPs may localize to the cell surface in association with adhesion receptors, and that MMP substrates include latent cytokines and growth factors, provide a new conceptual framework for the mechanisms whereby MMPs influence tumor behavior.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 035266416

Download citation: RISBibTeXText

PMID: 11170864

DOI: 10.1006/scbi.2000.0379


Related references

Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. Faseb Journal 7(15): 1434-1441, 1993

Extracellular matrix metalloproteinases in tumor invasion and metastasis. Cancer Treatment and Research 53: 421-440, 1991

The role of matrix metalloproteinases in tumor invasion and metastasis. Ginekologia Polska 77(1): 63-71, 2006

The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. Korean Journal of Gastroenterology 45(6): 401-408, 2005

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis. Cancer Metastasis Reviews 14(4): 351-362, 1995

The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis. Surgical Oncology Clinics of North America 10(2): 383-92, X, 2001

Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis. Biochemistry (Moscow) 68(7): 711-717, July, 2003

Regulation of matrix metalloproteinases - their role in tumor invasion and metastasis. International Journal of Oncology 2(6): 861-872, 1993

The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis. Hormone and Metabolic Research 35(11-12): 802-808, 2004

Matrix metalloproteinases: Promoters of tumor invasion and metastasis - A review with focus on gastrointestinal tumors. Zeitschrift für Gastroenterologie 39(9): 807-813, 2001

Matrix metalloproteinases: their structures and functions, with special reference to their roles in tumor invasion and metastasis. Seikagaku. Journal of Japanese Biochemical Society 68(12): 1791-1807, 1996

Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells. Cell Biology International 33(10): 1087-1094, 2009

Imbalance between Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Promotes Invasion and Metastasis of Head and Neck Squamous Cell Carcinoma. Clinical Laboratory 63(10): 1613-1620, 2017

Role of matrix metalloproteinases (MMPs) in tumor invasion and metastasis: serial studies on MMPs and TIMPs. Beijing Da Xue Xue Bao. Yi Xue Ban 35(4): 441-443, 2003

c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. Molecular Cancer 11: 15-15, 2012