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Mechanisms of motor neuron death in ALS


, : Mechanisms of motor neuron death in ALS. Beyreuther, Konrad [Editor, Reprint Author], Christen, Yves [Editor], Masters, Colin L [Editor] Neurodegenerative disorders: Loss of function through gain of function : 23-40


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Related references

Bruijn, L.I.; Cleveland, D.W., 1996: Mechanisms of selective motor neuron death in ALS: Insights from transgenic mouse models of motor neuron disease. Concerning the mechanism(s) of disease underlying amyotrophic lateral sclerosis (ALS), transgenic mouse models have provided (i) a detailed look at the pathogenic progression of disease, (ii) a tool for testing hypotheses concerning the mechanism...

Bruijn, L.I.; Cleveland, D.W., 1996: Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease. Concerning the mechanism(s) of disease underlying amyotrophic lateral sclerosis (ALS), transgenic mouse models have provided (i) a detailed look at the pathogenic progression of disease, (ii) a tool for testing hypotheses concerning the mechanism...

Cleveland, D.W.; Bruijn, L.I.; Wong, P.C.; Marszalek, J.R.; Vechio, J.D.; Lee, M.K.; Xu, X.S.; Borchelt, D.R.; Sisodia, S.S.; Price, D.L., 1996: Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. To examine the mechanism(s) of disease underlying ALS, transgenic mouse models have been constructed that express aberrant neurofilaments or mutations in the abundant, cytoplasmic enzyme superoxide dismutase 1 (SOD1). In addition to progressive we...

Cleveland, D.W., 1999: From Charcot to SOD1: mechanisms of selective motor neuron death in ALS. Neuron 24(3): 515-520

Shaw, P.J., 2001: Mechanisms of cell death and treatment prospects in motor neuron disease. Scientific evidence is emerging to indicate that motor neuron injury in motor neuron disease may reflect a complex interplay between genetic factors, oxidative stress, and imbalance of the glutamatergic excitatory control of motor neurons, which m...

Lee, M.K.; Marszalek, J.; Cleveland, D.W., 1993: Involvement of neurofilaments in motor neuron disease A point mutation in a neurofilament subunit causes massive, selective motor neuron death. Molecular Biology of the Cell 4(SUPPL ): 174A

Lee, M.K.; Marszalek, J.R.; Cleveland, D.W., 1994: A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. A direct role of aberrant neurofilament accumulation in the etiology of human motor neuron diseases, including amyotrophic lateral sclerosis, is suggested by the presence of abnormal accumulations of neurofilaments as an early hallmark of the path...

Nishitoh, H.; Ichijo, H., 2009: Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 54(3): 237-244

Tapia, R., 2014: Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis: a perspective. Frontiers in Cellular Neuroscience 8: 241-241

Martin, L., J.; Price, A., C.; Kaiser, A.; Shaikh, A., Y.; Liu, Z., 2000: Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review). Amyotrophic lateral sclerosis (ALS), also referred to as motor neurone disease, is a fatal neurological disease that is characterized clinically by progressive muscle weakness, muscle atrophy, and eventual paralysis. The neuropathology of ALS is p...