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Method for assaying non-spermine/spermidine activity of spermidine/spermine N1-acetyltransferase

Method for assaying non-spermine/spermidine activity of spermidine/spermine N1-acetyltransferase

Official Gazette of the United States Patent and Trademark Office Patents 1288(1)

ISSN/ISBN: 0098-1133

This invention relates to a method for assaying activity of the enzyme spermidine/spermine N1 -acetyltransferase (SSAT) using SSAT substrates by detecting acetylated forms of the SSAT substrates. SSAT substrates may include amantadine wherein metabolism of amantadine occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolite N-acetylamantadine.

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Accession: 035291223

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