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Method for in vivo modulation of non-malignant skin-related processes with 9 cis-retinoic acid


, : Method for in vivo modulation of non-malignant skin-related processes with 9 cis-retinoic acid. Official Gazette of the United States Patent & Trademark Office Patents 1219(4): 3376, Feb 23


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Duell, E.A.; Aström, A.; Griffiths, C.E.; Chambon, P.; Voorhees, J.J., 1992: Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro. Metabolism of retinoic acid to a less active metabolite, 4-hydroxyretinoic acid, occurs via cytochrome P-450 isozyme(s). Effect of a pharmacological dose of retinoic acid on the level of retinoic acid in skin and on cytochrome P-450 activity was i...

Duell E.; Astrom A.; Griffiths C.E.M.; Chambon P.; Voorhees J., 1991: Retinoic acid therapy of human skin in vivo stimulates cytochrome p 450 mediated transformation of retinoic acid into 4 hydroxy and 4 oxoretinoic acid which increase retinoic acid receptor dependent reporter gene transcription in vitro. Clinical Research 39(2): 472A

Park, N-H.; Park, J-S.; Kang, Y-G.; Bae, J-H.; Lee, H-K.; Yeom, M-H.; Cho, J-C.; Na, Y.J., 2013: Soybean extract showed modulation of retinoic acid-related gene expression of skin and photo-protective effects in keratinocytes. Soy extracts are well known as medicinal and nutritional ingredients, and exhibit benefits towards human skin including depigmenting or anti-ageing effects. Despite the wrinkle decreasing effects of retinoids on skin as an anti-ageing ingredient,...

Duell, E.A.; Kang, S.; Voorhees, J.J., 1996: Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only Trans retinoic acid. Application of all-trans retinoic acid to human skin for 4 d under occlusion produces a marked increase in retinoic acid 4-hydroxylase activity. In this study, the possible induction of other hydroxylases in response to 9-cis and 13-cis retinoic a...

Duell, E.A.; Kang, S.; Voorhees, J.J., 1996: Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid. Application of all-trans retinoic acid to human skin for 4 d under occlusion produces a marked increase in retinoic acid 4-hydroxylase activity. In this study, the possible induction of other hydroxylase in response to 9-cis and 13-cis retinoic ac...

Kang, S.; Duell, E.A.; Fisher, G.J.; Datta, S.C.; Wang, Z.Q.an; Reddy, A.P.; Tavakkol, A.; Yi, J.Y.; Griffiths, C.E.M.; Elder, J.T.; Voorhees, J.J., 1995: Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. We investigated the clinical, histologic, and molecular responses of normal human skin to all-trans-retinol (ROL) application, compared to those induced by topical all-trans-retinoic acid (RA), and measured ROL-derived metabolites. Up to 1.6% ROL,...

Voorhees, J.J.; Ellis, C.N.; Griffiths, C.E.M., 1998: Method of treatment of hyperpigmentation in black skin with retinoic acid and method of lightening black skin with retinoic acid. Official Gazette of the United States Patent & Trademark Office Patents 1210(2): 1560-1561, May 12

Reddy, A.P.; Fisher, G.J.; Datta, S.; Dunkle, W.; Venkatapuram, S.; Voorhees, J.J., 1993: Topical retinoic acid in human skin in vivo induces expression of cellular retinol binding protein I but not alcohol dehydrogenase 3, although the promoters of both genes contain consensus retinoic acid response elements. Journal of Investigative Dermatology 100(4): 553

Aström, A.; Tavakkol, A.; Pettersson, U.; Cromie, M.; Elder, J.T.; Voorhees, J.J., 1991: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. To investigate the role of CRABP in human skin we have cloned the human CRABP-II cDNA as well as the coding region of human C...

Astrom A.; Tavakkol A.; Pettersson U.; Cromie M.; Elder J.T.; Voorhees J.J., 1991: Molecular cloning of two human cellular retinoic acid binding proteins crabp retinoic acid induced expression of crabp ii but not crabp i in adult human skin in vivo and in skin fibroblasts in vitro. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. To investigate the role of CRABP in human skin we have cloned the human CRABP-II cDNA as well as the coding region of human C...