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Method to assess bioequivalence of topically delivered drug by intradermal microdialysis


, : Method to assess bioequivalence of topically delivered drug by intradermal microdialysis. Clinical Pharmacology & Therapeutics 65(2): 123, Feb


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Holmgaard, R.; Nielsen, J.B.; Benfeldt, E., 2010: Microdialysis sampling for investigations of bioavailability and bioequivalence of topically administered drugs: current state and future perspectives. Microdialysis (MD) in the skin is a unique technique for in vivo sampling of topically as well as systemically administered drugs at the site of action, e.g. sampling the unbound tissue concentrations in the dermis and subcutaneous tissue. MD as a...

Stagni, G.; O'donnell, D.; Liu, Y.J.an; Kellogg, D.L.Jr.; Morgan, T.; Shepherd, A.M.M., 2000: Intradermal microdialysis: Kinetics of iontophoretically delivered propranolol in forearm dermis. Intradermal microdialysis permits us to measure the concentration in dermis of drugs applied to the skin. Microdialysis is especially efficient in sampling water-soluble molecules. Consequently, it appears particularly suitable to study current ba...

Stagni, G.; O'Donnell, D.; Liu, Y.J.; Kellogg, D.L.; Morgan, T.; Shepherd, A.M., 1999: Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis. Intradermal microdialysis permits us to measure the concentration in dermis of drugs applied to the skin. Microdialysis is especially efficient in sampling water-soluble molecules. Consequently, it appears particularly suitable to study current ba...

Kreilgaard, M.; Kemme, M.J.B.; Burggraaf, J.; Schoemaker, R.C.; Cohen, A.F., 2001: Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics. Purpose: The aim of the study was to investigate the cutaneous bio-equivalence of a lipophilic model drug (lidocaine) applied in a novel topical microemulsion vehicle, compared to a conventional oil-in-water (O/W) emulsion, assessed by a pharmacok...

Benfeldt, E.; Hansen, S.H.; Vølund, A.; Menné, T.; Shah, V.P., 2006: Bioequivalence of topical formulations in humans: evaluation by dermal microdialysis sampling and the dermatopharmacokinetic method. The aim of this study was to evaluate the relationship between dermal microdialysis (DMD) sampling and the dermatopharmacokinetic method when employed simultaneously for bioequivalence (BE) investigations of topical formulations. Topical lidocain...

Siddoju, S.; Sachdeva, V.; Friden, P.M.; Banga, A.K., 2016: Iontophoretic delivery of acyclovir: intradermal drug monitoring using microdialysis and quantification by skin extraction. The objective of this study was to investigate the effect of iontophoresis on the intradermal and transdermal delivery of acyclovir using hairless rat skin on a vertical Franz diffusion cell. In this study, cathodal iontophoretic delivery of acycl...

Marston, S.A., 1996: Direct drug concentration profile comparisons to assess bioavailability and bioequivalence. Pharmaceutical Research (New York) 13(9 SUPPL ): S488

Inman, M.; Parameswaran, K.; Morris, M.; Summers, E.; Kamada, D.; Otis, J.; O'byrne, P.; Hargreave, F.E., 1998: Bronchoprotection of methcholine induced bronchoconstriction as a method to assess bioequivalence of CFC and HFA salbutamol. Clinical & Investigative Medicine (SUPPL ): S14

Wei, H.; Wang, S.; Xu, F.; Xu, L.; Zheng, J.; Chen, Y., 2015: Topical bioequivalence of acyclovir creams using dermal microdialysis in pigs: a new model to evaluate bioequivalence for topical formulations. The aim was to evaluate the bioequivalence of topically applied Acyclovir (ACV) creams using dermal microdialysis (DMD) in a pig model. Three ACV creams (3%), ACV1, ACV2 and ACV3, were topically administrated on the dorsum of pigs, and the DMD sam...

Stagni, G.; O'donnell, D.; Liu, Y.J.; Shepherd, D.L.J.K.llogg,and A.M.M., 1997: Evaluation of an intradermal microdialysis technique to study transdermal iontophoretic drug delivery in the forearm of human subjects Preliminary results. Pharmaceutical Research (New York) 14(11 SUPPL ): S69, Nov