Methylation-sensitive restriction fingerprinting

Davies, C.S.

Methods in Molecular Biology 200: 43-51

2002


ISSN/ISBN: 1064-3745
PMID: 11951654
DOI: 10.1385/1-59259-182-5:043
Accession: 035304558

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Abstract
Methylation of cytosine residues is an almost ubiquitous finding of higher organisms (1). The majority of this methylation occurs at the dinucleotide Cp G (where p denotes a phosphate group) (2). Cp G sites are distributed throughout the genome with clusters of the sequence being found in the 5′ promoter region of housekeeping genes, in groups known as Cp G islands.