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Mixed acetals of cyclodextrins Preparation of hexakis-, heptakis- and octakis methyl-alpha-, beta- and gamma-cyclodextrins



Mixed acetals of cyclodextrins Preparation of hexakis-, heptakis- and octakis methyl-alpha-, beta- and gamma-cyclodextrins



Carbohydrate Research 337(2): 93-96, 5 February



The proton-catalyzed addition of 2-methoxypropene to alpha-, beta- and gamma-cyclodextrins resulted in hexakis-, heptakis-, and octakis(2,6-di-O-(methoxydimethyl)methyl)-alpha-, beta- and gamma-cyclodextrins, but no reaction was observed of CD-s with 2,2-dimethoxypropane. The mixed acetal-type compounds can be alkylated under basic conditions. The preparation of hexakis(3-O-benzyl)-alpha-cyclodextrin demonstrates the synthetic value of this methodology.

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