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Multi-drug resistant Escherichia coli in a Veterinary Teaching Hospital Mechanisms of resistance



Multi-drug resistant Escherichia coli in a Veterinary Teaching Hospital Mechanisms of resistance



Abstracts of the General Meeting of the American Society for Microbiology 102: 514



Multi-drug resistant E. coli (MDREC) were isolated from 12 cases of nosocomial infections in hopsitalized dogs at The University of Queensland Veterinary Teaching Hospital. These isolates were resistant to almost every major class of antimicrobials including fluoroquinolones and 3rd generation cephalosporins. Imipenem and amikacin were the only antimicrobials to which all isolates were sensitive. These isolates phenotypically demonstrated extended-spectrum beta-lactamase (ESBL) production to at least one 3rd generation cephalosporin by Jarlier's double disk diffusion method. ESBL identification was performed by PCR amplification with specific primers for each major group of known beta lactamases. PCR and plasmid analysis identified the presence of multiple TEM genes in the isolates. MDREC isolates were also screened for Class I and related integrons, with PCR amplification and DNA sequencing demonstrating the presence of distinct gene cassettes including dfrV, aadA2 and dfrA17/aadA5. The results indicate that while all MDREC isolates examined in this study had similar antimicrobial susceptibility profiles, the genes involved in producing multiple antimicrobial resistance were varied and may reflect the promiscuous nature of mobile DNA elements.

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