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Multi-neuron recording and the effects of DA agonists on striatal neurons in young versus aged Fischer 344 rats



Multi-neuron recording and the effects of DA agonists on striatal neurons in young versus aged Fischer 344 rats



Society for Neuroscience Abstracts 26(1-2): Abstract No -873 7



Chronically implanted multi-neuron electrode arrays were used to record extracellular electrophysiological activity in the striatum of freely-moving young versus aged Fischer 344 rats. After a week of recovery, testing commenced with the discrimination of individual neurons. Rats were first administered saline and then either low-dose apomorphine (APO; 0.05 mg/kg) or high-dose amphetamine (AMP; 5.0 mg/kg). Analyses of individual neurons revealed that while basal striatal firing rate did not differ between the two age groups, bursting activity was greater in the old rats. Low-dose APO produced an overall decrease in mean striatal firing rates and percentage of spikes within bursts, the latter effect being greater in the younger rats. AMP produced overall a) increases in mean firing rates of striatal neurons and percentage of spikes within bursts and b) decreases in burst durations, rate of firing within bursts, and interspike intervals within bursts. The effects of AMP on percentage of spikes in bursts and firing rates within bursts were greater in the aged rats. Interestingly, when neurons were classified according to their response to AMP, units that were decreased by the drug demonstrated significantly lower basal firing rats in the older rats. Overall, these results suggest age-related changes in the responsivity of striatal neurons.

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