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Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides



Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides



Official Gazette of the United States Patent & Trademark Office Patents 1259(1), June 4



A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.

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Accession: 035349426

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