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Multi-site evaluation of gatifloxacin, moxifloxacin, cefotaxime, cefdinir, and meropenem comparing Haemophilus influenzae on both the Sensititre dried susceptibility panel and the NCCLS microdilution method



Multi-site evaluation of gatifloxacin, moxifloxacin, cefotaxime, cefdinir, and meropenem comparing Haemophilus influenzae on both the Sensititre dried susceptibility panel and the NCCLS microdilution method



Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 42: 131



A multi-site evaluation was undertaken to compare the performances of five antimicrobials on the Sensititre 18-24 hour dried susceptibility panel (test panel) to results obtained with the NCCLS microdilution reference method when tested with H. influenzae. The antimicrobials tested along with their drug ranges were gatifloxacin (0.002-8 mug/ml), moxifloxacin (0.004-8 mug/ml), cefotaxime (0.016-4 mug/ml), cefdinir (0.016-4 mug/ml), and meropenem (0.016-2 mug/ml). The clinical evaluation was conducted at two trial sites and consisted of 212 fresh clinical H. influenzae isolates, 50 H. influenzae challenge isolates and appropriate quality control strains. Reproducibility testing was performed on 10 selected isolates in triplicate for three separate days. Reproducibility results for each of the five drugs tested were 97.2% for gatifloxacin, 97.8% for moxifloxacin, 96.1% for cefotaxime, 90.6% for cefdinir, and 97.8% for meropenem. Essential agreements were calculated by determining whether an isolate's test panel result was within a+-1 well dilution compared to the reference panel's result. Categorical agreements were calculated by comparing each isolate's test panel susceptibility result (sensitive, intermediate, or resistant) to its reference panel's susceptibility result. The total essential and categorical agreements for each of the five drugs were as follows: 98.1% and 100% for gatifloxacin, 97.3% and 100% for moxifloxacin, 94.3% and 100% for cefotaxime, 88.2% and 95.0% for cefdinir, 98.9% and 97.7% for meropenem. This multi-site evaluation indicates that the performances of gatifloxacin, moxifloxacin, cefotaxime, cefdinir, and meropenem on the Sensititre 18-24 hour susceptibility system were equivalent to their results using the NCCLS microdilution reference method.

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Accession: 035349521

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