+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Multi-stage drug delivery system



Multi-stage drug delivery system



Official Gazette of the United States Patent & Trademark Office Patents 1244(4), Mar 27



A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system (10) and method by which the drug delivery system (10) provides the drug to a body.

(PDF emailed within 1 workday: $29.90)

Accession: 035349570

Download citation: RISBibTeXText


Related references

Method for making a multi-stage drug delivery system. Official Gazette of the United States Patent & Trademark Office Patents 1203(1): 375, Oct 7, 1997

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials 32(30): 7711-7720, 2011

Drug releasing characteristics evaluation to multi-drug delivery system of tongmai pellets. Zhongguo Zhong Yao Za Zhi 37(19): 2889-2893, 2013

Progress in the study of drug delivery system based on nanoparticles to overcome multi-drug resistance. Yao Xue Xue Bao 44(4): 333-337, 2010

Multi-stage delivery system for ingestible medications or nutrients. Official Gazette of the United States Patent & Trademark Office Patents 1205(5): 3810, Dec 30, 1997

Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant breast cancer therapy. Acs Applied Materials & Interfaces 6(9): 6469-6480, 2015

Delivery system for deployment and endovascular assembly of a multi-stage stented graft. Official Gazette of the United States Patent & Trademark Office Patents 1249(4), Aug 28, 2001

Delivery system for development and endovascular assembly of a multi-stage stented graft. Official Gazette of the United States Patent & Trademark Office Patents 1271(1), June 3, 2003

Pharmacokinetics and tissue distribution studies of orally administered nanoparticles encapsulated ethionamide used as potential drug delivery system in management of multi-drug resistant tuberculosis. Drug Delivery 18(1): 65-73, 2011

Rationale for immunotoxin therapy of metastatic prostate carcinoma formatted as a multi-stage delivery system. Journal of Urology 142(2 Pt 1): 425-432, 1989

Multi-stage tandem mass spectrometric analysis of novel β-cyclodextrin-substituted and novel bis-pyridinium gemini surfactants designed as nanomedical drug delivery agents. Rapid Communications in Mass Spectrometry 28(7): 757-772, 2014

A multi-drug delivery system with sequential release using titania nanotube arrays. Chemical Communications 48(27): 3348-3350, 2012

Preparation and evaluation of multi particulates drug delivery system using natural polymers. Current Drug Delivery 12(3): 314-322, 2016

Hydrogel integrated with liposome: a two-stage drug delivery system. Journal of Controlled Release 152 Suppl 1: E63-E64, 2012

Salt metathesis for developing injectable supramolecular metallohydrogelators as a multi-drug-self-delivery system. Chemical Communications 52(95): 13811-13814, 2016