+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Multi-well single-membrane permeation device and methods

Multi-well single-membrane permeation device and methods

Official Gazette of the United States Patent & Trademark Office Patents 1232(4), Mar 28

The invention provides exemplary testing devices, systems, and methods for evaluating the permeation of various chemicals through different types of cells. In one exemplary embodiment, a testing device is provided which comprises a base member and a top member having a plurality of wells which are aligned when the top member is secured to the base member. A membrane sheet which includes at least one layer of cells grown on the sheet is placed between the base member and the top member prior to assembly. Test samples are placed into the wells in the top member and samples are removed from the top and bottom wells at a later time and tested to determine the amount of test sample which permeated through the cells.

(PDF 0-2 workdays service: $29.90)

Accession: 035349661

Download citation: RISBibTeXText

Related references

Membrane permeation-controlled transdermal delivery system design. Influence of controlling membrane and adhesive on skin permeation of isosorbide dinitrate. Chemical & Pharmaceutical Bulletin 38(3): 740-743, 1990

Single-file diffusion multi-ion mechanism of permeation in paracellular epithelial channels. Journal of Membrane Biology 64(1-2): 103-112, 1982

Ionic channels of the sugar beet tonoplast are regulated by a multi-ion single-file permeation mechanism. Journal Of Membrane Biology. 154(1): 69-79, 1996

The use of permeation tube device and the development of empirical formula for accurate permeation rate. Journal of Chromatography. A 1218(52): 9328-9335, 2012

A Membrane-integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines. Analytical Sciences 32(12): 1307-1314, 2016

Water permeation through single-layer graphyne membrane. Journal of Chemical Physics 139(6): 064705-064705, 2013

Single-crystal membrane for anisotropic and efficient gas permeation. Journal of the American Chemical Society 132(9): 2862-2863, 2010

Conformational model for ion permeation in membrane channels: a comparison with multi-ion models and applications to calcium channel permeability. Biophysical Journal 63(2): 485-496, 1992

Characterization of a liposome-based artificial skin membrane for in vitro permeation studies using Franz diffusion cell device. Journal of Liposome Research (): 1-10, 2016

Nickel (II) Preconcentration and Speciation Analysis During Transport from Aqueous Solutions Using a Hollow-fiber Permeation Liquid Membrane (HFPLM) Device. Membranes 1(3): 217-231, 2011

Controlled permeation of cell membrane by single bubble acoustic cavitation. Journal of Controlled Release 157(1): 103-111, 2012

Membrane structure and ion permeation. Study of ion exchange membrane structure and function is relevant to analysis of biological ion permeation. Science 155(3765): 965-974, 1967

On-line coupling of flow through voltammetric microcell to hollow fiber permeation liquid membrane device for subnanomolar trace metal speciation measurements. Electroanalysis 13(16): 1305-1314, November, 2001

Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage. Official Gazette of the United States Patent & Trademark Office Patents 1231(1), Feb 1, 2000

Permeation of redox species through a cell membrane of a single, living algal protoplast studied by microamperometry. Biochimica Et Biophysica Acta. 1369(1): 152-158,. 2, 1998