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Multibinding inhibitors of HMG-CoA reductase



Multibinding inhibitors of HMG-CoA reductase



Official Gazette of the United States Patent & Trademark Office Patents 1256(2), Mar 12



Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-COA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to HMG-CoA reductase and the distance between ligands is at least 10 ANG. The multibinding compounds of this invention are useful in the treatment and prevention of hypercholesterolemia, hyperlipidemia, atherosclerosis and the like.

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Accession: 035349695

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