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Multibinding inhibitors of cyclooxygenase-2

Multibinding inhibitors of cyclooxygenase-2

Official Gazette of the United States Patent and Trademark Office Patents 1258(4)

Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.

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Accession: 035349696

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