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Multibinding inhibitors of microsomal triglyceride transferase protein



Multibinding inhibitors of microsomal triglyceride transferase protein



Official Gazette of the United States Patent & Trademark Office Patents 1250(2), Sep 11



Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 to 10 ligands covalently attached to one or more linkers. The multibinding compounds of this invention are useful for lowering serum lipid, cholesterol and/or triglyceride levels, and for preventing and treating disorders associated with hyperlipemia, hyperlipidemia, hyperlipoproteinemia, hypercholestrolemia, hypertriglyceridemia and the like, such atherosclerosis.

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Accession: 035349697

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