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Multicenter evaluation of the new MicroScan rapID/S plus antimicrobial susceptibility test system with gram-negative bacteria and fluoroquinolones



Multicenter evaluation of the new MicroScan rapID/S plus antimicrobial susceptibility test system with gram-negative bacteria and fluoroquinolones



Abstracts of the General Meeting of the American Society for Microbiology 101: 203-204



Rapid susceptibility tests for gram-negative bacteria have the potential to improve patient care by allowing the clinician to initiate appropriate therapy sooner. The new MicroScan rapID/S plus AST System for gram-negative bacteria was evaluated in a multicenter study with fresh and stock clinical isolates. The new system combines early (4.5-5.5 h) MIC results with the capability to hold and read panels incrementally up to 18 h and uses standard MicroScan Dried Overnight Panels. The accuracy of the new rapID/S plus AST system with fluoroquinolones was evaluated at three sites by comparing the performance of the new system to an NCCLS broth microdilution reference panel. There were 291 fresh and 236 stock gram-negative isolates tested against ciprofloxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, and sparfloxacin. Essential agreement (+/- one doubling dilution) between the test system and the reference method ranged from 97.0% for norfloxacin to 99.6% for both lomefloxacin and ofloxacin. Absolute categorical agreement based on interpretation ranged from 93.0% for ciprofloxacin to 96.2% for sparfloxacin. Major error rates were 0% for lomefloxacin, levofloxacin, and sparfloxacin and 0.2% for ciprofloxacin, norfloxacin, and ofloxacin. Very major error rates were 0% for ciprofloxacin, lomefloxacin, and norfloxacin, 1.0% (1/103) for sparfloxacin, 1.1% (1/88) for ofloxacin, and 3.1% (2/65;1 C. freundii, 1 P. penneri) for levofloxacin. Levofloxacin is not intended for use against C. freundii or P. penneri. This study showed that the new MicroScan rapID/S plus AST system for gram-negative bacteria correlates well with an NCCLS broth microdilution reference panel for the fluoroquinolones tested.

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