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Multicenter prospective validation of a simple endoscopic score for crohns disease



Multicenter prospective validation of a simple endoscopic score for crohns disease



Digestive Disease Week Abstracts & Itinerary Planner : Abstract No S1343



Background: Endoscopic healing has become one of the major goals of Crohn s disease (CD) therapy. The gold standard for CD endoscopic evaluation is the Crohn s disease endoscopic index of severity (CDEIS), which is time consuming and difficult to use. SES-CD has been proposed as a simpler alternative (1). Aims: To evaluate SES-CD reproducibility and clinical correlations. Methods: Clinical history, CDAI and IBDQ were recorded. Blood was drawn for CRP and blood count. CDEIS and SES-CD were independently scored by a pair of experienced endoscopists. The following lesions were assessed in the 5 classic ileocolonic segments: Results: Sixty-two patients were studied. The mean number of ileocolonic segments explored per procedure was 4.6 (range 3-5). Interobserver agreement for SES-CD variables was good to excellent for all segments, with kappa values ranging between 0.76 and 1.00. The interobserver correlation for SES-CD was significantly closer than for the CDEIS (r=0.97 vs 0.87, p<0.0001). Correlations of SES-CD to CRP and CDAI were significant (p<0.002), but not very close (r=0.39 and 0.41), and not significantly better than CDEIS correlations (0.26 and 0.36). Conclusions: This prospective validation study confirmed the reproducibility of the SES-CD. SES-CD is at least as reliable as CDEIS, but is simpler to be scored. Further validation is ongoing.

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Accession: 035349890

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