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Multicentre Case-Control Study on Hepatitis C Virus and Lymphoproliferative Disorders

Multicentre Case-Control Study on Hepatitis C Virus and Lymphoproliferative Disorders

Blood 100(11): Abstract No 754, November 16

Background/aims: Hepatitis C virus (HCV) has been found associated with mixed cryoglobulinemia and with B cell non Hodgkin lymphoma (B-NHL). The studies reporting an association between HCV and B-NHL are not univocal and have several limitations such us the use of prevalent cases and use of inappropriate control groups. The present study is a multicentre case-control study conducted from January 1998 until February 2001. Methods:All cases were new diagnosis of not pre-treated Lymphoproliferative disorders and the controls were enrolled during the study period from department of traumatology, ortopetic, ophthalmology, surgery, gynaecology, otorhinolaryngology, medicine, dermatology and dentistry in the same hospitals where cases were identified. Anti-HCV antibodies were detected by 3rd generation ELISA and RIBA tests. A commercial PCR test was used for detection of serum HCV-RNA and genotyping was performed by Inno-LIPA. Adjusted odds ratios and their 95% confidence intervals were computed using multivariate logistic regression model. Results: Totally 1138 cases and 396 controls were analysed. The anti-HCV prevalence among controls was 5.6%, while among the 401 B-NHL was 17.7% with an adjusted OR of 3.1 (95% CI= 1.9-5.2) An elevated OR was found in low grade as well as high grade NHL. When genotype distribution was analysed in NHL and controls, 1b and 2a/2c were present in the 42% and 45% respectively of NHL and in 50% and 44% of control group. Conclusions: Our study, conducted in different geographical areas of Italy using incident cases, confirms an association between anti-HCV and NHL. No role of specific HCV genotype was found.

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Accession: 035349998

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