+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neurophysiological findings and drinking levels in high-alcohol-drinking and low-alcohol-drinking rats



Neurophysiological findings and drinking levels in high-alcohol-drinking and low-alcohol-drinking rats



Alcoholism Clinical & Experimental Research 24(10): 1492-1499



Background: Specific neurophysiological profiles, such as reduced P300 amplitude or altered spectral power in the EEG, have been associated with a risk for alcoholism in several clinical populations. In certain rodent models, high versus low alcohol consumption is associated with similar neurophysiological differences. For example, alcohol-preferring (P) rats have increased spectral power and decreased P300 amplitudes compared with alcohol-nonpreferring (NP) rats. In the present study, the neurophysiological profiles of high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were assessed (1) to determine if their electrophysiological profiles are similar to P and NP rats and (2) to examine the relationship of these neurophysiological indices to ethanol drinking. Methods: Ethanol-naive HAD and LAD rats were implanted with cortical and amygdalar recording electrodes. Baseline EEG and event-related potentials (ERPs) then were assessed. Subsequently, all rats were trained to self-administer ethanol by using a sucrose-substitution procedure. Results: Baseline EEG and ERP (i.e., pre-ethanol exposure) were assessed based on line (HAD versus LAD) and actual ethanol consumption (high drinkers versus low drinkers). At baseline, ethanol-naive HAD rats displayed significantly greater power in the cortical EEG and decreased amygdala N1 ERP amplitude compared with ethanol-naive LAD rats. Similar EEG and ERP profiles have been observed when P and NP rats are compared. No differences in P300 between lines were observed, but high-drinking rats, independent of line, had significantly decreased P300 amplitude in the amygdala compared with low-drinking rats. Conclusions: These data suggest there are some similarities in EEG and ERP profiles of P and HAD rats compared with NP and LAD rats. Furthermore, the data suggest that decreased P300 amplitude in the amygdala is associated with increased limited access ethanol drinking.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 035381970

Download citation: RISBibTeXText


Related references

Neurophysiological findings and drinking levels in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. Alcoholism Clinical and Experimental Research 24(10): 1492-1499, 2000

Neurophysiological profiles of High Alcohol Drinking and Low Alcohol Drinking rats Relationship to limited access ethanol consumption. Alcoholism Clinical & Experimental Research 24(5 Suppl.): 8A, 2000

Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: modeling adolescent and adult binge-like drinking. Alcohol 48(3): 225-234, 2015

Neurophysiological profiles of replicate line 2 high-alcohol-drinking (HAD-2) and low-alcohol-drinking (LAD-2) rats. Alcoholism Clinical and Experimental Research 26(11): 1669-1677, 2002

Neurophysiological profiles of replicate line 2 high-alcohol-drinking and low-alcohol-drinking rats. Alcoholism Clinical & Experimental Research 26(11): 1669-1677, 2002

Quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rats were confirmed in the replicate rat lines. Alcoholism Clinical & Experimental Research 27(5 Suppl.): 47A, 2003

Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4). Psychopharmacology 232(13): 2251-2262, 2016

Local cerebral glucose utilization rates in alcohol-naïve high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. Alcoholism, Clinical and Experimental Research 25(4): 517-523, 2001

Local cerebral glucose utilization rates in alcohol-naive high-alcohol-drinking and low-alcohol-drinking rats. Alcoholism Clinical & Experimental Research 25(4): 517-523, 2001

Taste reactivity and consumption as measures of alcohol palatability in high alcohol drinking and low alcohol drinking rats. Society for Neuroscience Abstracts 18(1-2): 541, 1992

Selective breeding for high alcohol consumption and response to nicotine: locomotor activity, dopaminergic in the mesolimbic system, and innate genetic differences in male and female alcohol-preferring, non-preferring, and replicate lines of high-alcohol drinking and low-alcohol drinking rats. Psychopharmacology 235(9): 2755-2769, 2018

Alcohol-illness associations in the selectively bred high alcohol drinking and low alcohol drinking rats. Society for Neuroscience Abstracts 18(1-2): 541, 1992

Quantitative Autoradiography on [(35)S]TBPS Binding Sites of Gamma- Aminobutyric Acid(A) Receptors in Discrete Brain Regions of High- Alcohol-Drinking and Low-Alcohol- Drinking Rats Selectively Bred forHigh- and Low-Alcohol Preference. Journal of Biomedical Science 4(6): 308-314, 2002

Calcitonin gene-related peptide (CGRP) content and CGRP receptor binding sites in discrete forebrain regions of alcohol-preferring vs. -nonpreferring rats, and high alcohol-drinking vs. low alcohol-drinking rats. Brain Research 690(2): 249-253, 1995

Effects of acute ethanol on local cerebral glucose utilization in high alcohol-drinking and low alcohol-drinking rats. Alcoholism Clinical & Experimental Research 25(5 Suppl. A): 117A, 2001