Nucleic acid encoding urate transporter and methods of use thereof

Abramson, R.G.; Leal Pinto, E.; Lipkowitz, M.

Official Gazette of the United States Patent and Trademark Office Patents 1269(4)


ISSN/ISBN: 0098-1133
Accession: 035412519

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The present invention provides an isolated nucleic acid encoding a urate transporter, vectors comprising the nucleic acid, host cells comprising the nucleic acid, and host cells comprising the vectors. Compositions comprising the vectors and a carrier are also provided. In another embodiment, the present invention provides isolated and substantially purified urate transporter. Proteoliposomes containing substantially purified urate transporter are also provided, as well as compositions comprising the urate transporter and a carrier. The present invention further provides methods of making a urate transporter, and methods of identifying agents that inhibit or agonize the transporter.