Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof

Busfield, S.J.; Villeval, J.L.c

Official Gazette of the United States Patent and Trademark Office Patents 1247(2)


ISSN/ISBN: 0098-1133
Accession: 035412626

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The invention provides isolated TANGO 268 nucleic acid molecules and polypeptide molecules. TANGO 268 encodes a polypeptide that represents glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.