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Plasmodium falciparum MHC class I-restricted CTL epitopes derived from pre-erythrocytic stage antigens


Plasmodium falciparum MHC class I-restricted CTL epitopes derived from pre-erythrocytic stage antigens



Official Gazette of the United States Patent and Trademark Office Patents 1227(4)



ISSN/ISBN: 0098-1133

A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a "motif" of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed.

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Accession: 035510200

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