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Polyadp - ribosylation is a correlate of long - term memory after training inducing long - term sensitization of withdrawal reflexes in Aplysia



Polyadp - ribosylation is a correlate of long - term memory after training inducing long - term sensitization of withdrawal reflexes in Aplysia



Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 92 9



PolyADP-ribosylation is a transient posttranslational modification of DNA-bound proteins that induces chromatin alterations. It is catalyzed mainly by polyADP-ribose-polymerase-1 (PARP-1). We examined polyADP-ribosylation in response to training giving rise to long-term sensitization of withdrawal reflexes, and its neural correlate, long-term facilitation of sensory to motor neuron synapses.Training consisted of 4 spaced shocks to one side of Aplysia, which elicits ipsilateral long-term sensitization of withdrawal reflexes, and ipsilateral long-term facilitation of sensory to motor neurons synapses in the pleural and pedal ganglia. The training procedure caused an increase in polyADP-ribosylation in the pleural and pedal ganglia ipsilateral, but not contralateral to the shock.Long-term facilitation can be elicited by 5 spaced applications of 5-HT to the isolated pleural-pedal ganglia. This treatment led to increased polyADP-ribosylation in the pleural and pedal ganglia. In contrast, one or three treatments, which cause short-term facilitation, did not stimulate polyADP-ribosylation. PolyADP-ribosylation was suppressed by pretreatment with 3-aminobenzamide (3-AB), a specific inhibitor of PARP-1. In addition, 5 spaced applications of FMRF-amide, which causes long-term depression, did not increase polyADP-ribosylation. These data indicate that polyADP-ribosylation is a correlate of only long-term facilitation.PolyADP-ribosylation has previously been regarded as functioning in cell death or repair in response to cell damage. Our results suggest that this reaction also has a role in the formation of long-term memory, presumably by altering the structure of chromatin, and thereby regulating gene expression.

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