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Prevalence and sequence of the beta-chemokine receptor CCR5-DELTA32 deletion allele in the Lebanese population



Prevalence and sequence of the beta-chemokine receptor CCR5-DELTA32 deletion allele in the Lebanese population



FASEB Journal 17(4-5): Abstract No 366 8



Early findings show that the incidence and distribution of the (-chemokine receptor 5 gene (CCR5-?32) deletion vary among the world's people. While homozygous deletion is about 1% and heterozygous deletion is 10 to 20% in North America and Europe, it is 4 to 5% in Mediterranean populations. On the other hand, several studies from parts of Africa, Haiti and Venezuela have not detected the ?32 base-pair deletion.Hereby, we report the frequency and sequence of homozygous and heterozygous CCR5-?32 deletion in a sample of the Lebanese population.PCR using primers that encompass the deletion was performed on genomic DNA from 209 individuals from different regions of Lebanon attending Saint George General Hospital. The polymorphism was detected by agarose gel electrophoresis.Homozygous mutants (?32/?32) were not detected; heterozygous (WT/?32) individuals represented 4.8% (allele frequency 2.5%) of our study group. DNA sequence of the wild type and mutated PCR products were confirmed.The frequency and sequence of CCR5-?32 are similar to that reported for South European and Mediterranean populations.

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