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Process for preparing camptothecin


, : Process for preparing camptothecin. Official Gazette of the United States Patent & Trademark Office Patents 1245(3), Apr 17

A process for preparing the anti-cancer drug camptothecin (CPT) and certain derivatives thereof. The process includes the reacting of three base reagents and a five-step process for synthesizing optically pure CPT in high overall yield from inexpensive starting materials.

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Accession: 035558960

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Il, H.C.ung; Kim, J.W.o; Lee, S.J.on; Ahn, S.K.l; Choi, N.S.ng; Kim, K.K.ang; Jeong, B.S.on, 2001: Process of preparing camptothecin derivatives. A process of preparing camptothecin derivatives of formula 1 is disclosed ##STR1##

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Henegar, Kevin E., 2004: Compounds useful in preparing camptothecin derivatives. Novel compounds are provided having the formula ##STR1## and salt thereof, where R1 is hydrogen, an alkyl, aralkyl, hydroxymethyl, carboxymethyl acyloxymethyl or trialkylsilyl group, or a group --CH2 NR3 R4 where N is a linking nitrogen atom and w...

Fraier, D.; Frigerio, E.; Brianceschi, G.; Casati, M.; Benecchi, A.; James, C., 2000: Determination of MAG-Camptothecin, a new polymer-bound Camptothecin derivative, and free Camptothecin in dog plasma by HPLC with fluorimetric detection. A high throughput. selective and sensitive high-performance liquid chromatographic (HPLC) method for the determination of a water-soluble polymer-bound Camptothecin conjugate (MAG-CPT) and Camptothecin (CPT) in dog plasma has been developed and va...

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