+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prolactin receptor heterogeneity: processing and signalling of the long and short isoforms during development

Prolactin receptor heterogeneity: processing and signalling of the long and short isoforms during development

Biochemical Society Transactions 29(Pt 2): 52-56

During development, the fetus is exposed to prolactin activity from the placenta, as well as from the developing fetal pituitary. Distinct prolactin receptor isoforms, having different cytoplasmic domains generated by alternative splicing, are expressed as development proceeds at different levels in different organs. The 'long' receptors are able to mediate transduction of all signals examined, in contrast with the 'short' isoforms, whose truncated cytoplasmic domains are able to mediate a much smaller repertoire of signals and can act as dominant negatives. Our studies demonstrate that, although these forms share internalization mechanisms, the long form is internalized faster, resulting in more rapid down-regulation of this form. In order to examine the mechanisms by which prolactin may exert trophic effects on its target tissues during development, we have examined the signalling pathways through which prolactin binding to the long receptor regulates the transcription of cyclin D1. Our studies reveal the importance of the JAK/STAT (Janus kinase/signal transduction and activators of transcription) pathway, and the complexity of prolactin signalling to this promoter.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 035569116

Download citation: RISBibTeXText

PMID: 11356126

DOI: 10.1042/bst029a019a

Related references

Reproductive actions of prolactin mediated through short and long receptor isoforms. Molecular and Cellular Endocrinology 382(1): 400-410, 2014

Comparison of the signalling properties of the long and short isoforms of the rat thyrotropin-releasing-hormone receptor following expression in rat 1 fibroblasts. Biochemical Journal 310: 291-298, 1995

The short of long isoforms of the dopamine D2 receptor differentially regulate prolactin synthesis and release in the lactotrophs. Society for Neuroscience Abstracts 23(1-2): 589, 1997

The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of the D2 receptor regulating prolactin release and cAMP. Society for Neuroscience Abstracts 27(2): 1766, 2001

Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. Journal of Biological Chemistry 288(48): 34943-34955, 2013

Effect of postnatal development on dopamine D2 receptor mRNA isoforms short and long in rabbit carotid body. Pediatric Research 37(4 Part 2): 57A, 1994

Subcellular distribution of the long and short isoforms of the growth hormone (GH) receptor in rat adipocytes: both isoforms participate in specific binding of GH. Endocrinology 134(1): 307-314, 1994

Human prolactin receptor variants in breast cancer: low ratio of short forms to the long-form human prolactin receptor associated with mammary carcinoma. Cancer Research 64(16): 5677-5682, 2004

Comparison of long and short forms of the prolactin receptor on prolactin induced milk protein gene transcription. Proceedings of the National Academy of Sciences of the United States of America 88(3): 824-828, 1991

Impact of subdomain D1 of the short form S1b of the human prolactin receptor on its inhibitory action on the function of the long form of the receptor induced by prolactin. Biochimica et Biophysica Acta 1840(7): 2272-2280, 2014

Prolactin receptors in sheep ovary Regulated expression of the long but not the short prolactin receptor isoform throughout the estrous cycle. Theriogenology 59(1): 412, 2003

Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Biology of Reproduction 86(3): 86, 2012

Gene structure and seasonal expression of carp fish prolactin short receptor isoforms. Journal of Cellular Biochemistry 100(4): 970-980, 2007

Localization of the mRNAs for the short and long isoforms of the dopamine D2 receptor in embryonic striatal grafts: predominance of the short isoform. Neuroreport 6(1): 41-45, 1994