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Pulmonary gene expression of antioxidant enzymes in a murine model of asthma


Pulmonary gene expression of antioxidant enzymes in a murine model of asthma



FASEB Journal 18(4-5): Abstract 148



ISSN/ISBN: 0892-6638

The respiratory system is frequently exposed to oxidants inhaled or released by cells in the lungs during inflammation. Glutathione (GSH) is a thiol-containing peptide. It plays important roles in antioxidant defense through chemical reactions of conjugation and oxidation mediated by glutathione S-transferases (GST) and glutathione peroxidases (GPX), respectively. Asthma is featured by chronic inflammation and oxidative stress in the lung. However, the effect of allergic inflammation on pulmonary gene expression of antioxidant enzymes (GST and GPX) in asthma is not clear. To address this issue, female BALB/c mice (eight weeks) were i.p. immunized with 100 mug ovalbumin (OVA) emulsified in alum on days 1, 7, and 14, then were i.n. challenged with 30 mug OVA on days 21, 28, 35, 42, 49, and 56. The controls were administered with saline. This model is characterized by increased pulmonary recruitment of eosinophils, goblet cell hyperplasia, epithelial damage, subepithelial fibrosis, and airway hyperreactivity. Pulmonary mRNA expressions of the alpha1, alpha2, mu1, mu2, mu4, mu6, pi2, and theta3 subclasses of GST, as well as subclasses 3 and 4 of GPX were found to be significantly decreased in this model, compared with controls. This finding suggests that allergic inflammation may lead to a decrement of anti-oxidant gene expression, and the resultant pulmonary accumulation of oxidants may further increase the severity of asthma. Funded by: Dalian Sci-Tech Bureau (2003 D4 NF090).

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Accession: 035586918

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