+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Serum beta-2 microglobulin as a prognostic factor in patients with Hodgkins lymphoma treated with A BVD or equivalent regimens with or without radiation therapy



Serum beta-2 microglobulin as a prognostic factor in patients with Hodgkins lymphoma treated with A BVD or equivalent regimens with or without radiation therapy



Blood 102(11): 273b, November 16



Serum beta-2 microglobulin (sbeta2m) is an established prognostic factor for multiple myeloma, non-Hodgkin's lymphoma, and B-chronic lymphocytic leukemia. However only the MD Anderson group has produced data suggesting an adverse prognostic role of sbeta2m in HL. Data from homogenously and optimally treated patient populations with HL are missing from the literature. We evaluated the impact of sbeta2m levels on the prognosis of 334 patients with HL, who were trated with ABVD or equivalent regimens with or without RT. sbeta2m levels were measured in pretreatment serum samples by a radioimmunoassay (upper normal limit 2.4 mg/l). Patients' characteristics were as follows: Median age 30 years (14-78); 54% males; 70% nodular sclerosis, 18% mixed cellularity, and 12% lymphocyte predominance; 33% B-symptoms; 26% Ann Arbor stage (AAS) I, 49% II, 17% III, and 9% IV; 14% gtoreq5 involved anatomic sites (IAS); 19% inguinal and/or iliac involvement; 38% anemia; 13% leukocytosis; 13% lymphocytopenia; 44% ESRgtoreq50; 28% serum albumin <4 g/dl; 28% elevated serum LDH. Elevated sbeta2m levels were detected in 112/334 patients (34%) and correlated strongly with all the above named clinical and laboratory parameters (p<0.01 for all comparisons), except of gender. With 48 events recorded so far, the 10-year failure free survival (FFS) was 75% vs. 69% for patients with normal vs. elevated sbeta2m levels (p=0.07). The corresponding 10-year overall survival (OS) rates were 88% vs. 60% (p=0.001). There was no evidence for a dose-response effect of sbeta2m on FFS or OS, e.g. the outcome of patients with significantly or only slightly elevated sbeta2m levels did not differ. In univariate analysis FFS was significantly influenced by the presence of B-symptoms, AAS IV, gtoreq5 IAS, inguinal/iliac involvement, anemia, albumin <4 g/dl, ESR gtoreq50, and elevated LDH. In multivariate analysis elevated sbeta2m levels were not predictive of FFS (p=0.18). The only independent prognostic factor was the number of IAS (p<0.001), while the significance of AAS IV was marginal (p=0.07). The inclusion of serum LDH (available in 86% of the patients) further reduced the level of significance of serum sb2m (p=0.59). However sbeta2m levels were independently associated with inferior OS (p=0.004), along with the number of IAS (p=0.002). Our data suggest that sbeta2m levels are not a potent prognostic factor for FFS in patients with HL treated with ABVD or equivalent regimens. This conclusion came from the analysis of a large series of homogenously treated HL patients (n=334), with 48 events recorded so far, which also failed to demonstrate a dose-response effect between sbeta2m levels and the outcome of the patients. The prognostic role of sbeta2m may be more significant with respect to OS.

(PDF emailed within 1 workday: $29.90)

Accession: 035717832

Download citation: RISBibTeXText


Related references

beta(2)-microglobulin in Hodgkin's lymphoma: prognostic significance in patients treated with ABVD or equivalent regimens. Journal of B.U.On. 10(1): 59-69, 2007

Serum interleukin-10 levels are a potent, independent prognostic factor for Hodgkins lymphoma , treated with standard chemotherapy regimens. Blood 96(11 Part 1): 727a, November 16, 2000

Prognostic relevance of serum beta2 microglobulin in patients with follicular lymphoma treated with anthracycline-containing regimens. A GISL study. Haematologica 92(11): 1482-1488, 2007

Prognostic significance of serum beta-2 microglobulin level in Hodgkin lymphoma treated with ABVD-based therapy. Medical Oncology 31(9): 185-185, 2015

Prognostic value of pretreatment serum beta-2 microglobulin level in advanced classical Hodgkin lymphoma treated in the modern era. Oncotarget (): -, 2016

Prognostic significance of serum beta-2 microglobulin in patients with non-Hodgkin lymphoma. Oncology 87(1): 40-47, 2014

Serum beta-2 microglobulin as a prognostic biomarker in patients with mantle cell lymphoma. Hematological Oncology 34(1): 22-27, 2016

Second malignancies in patients treated with radiation therapy for Hodgkins lymphoma. International Journal of Radiation Oncology Biology Physics 54(2 Supplement): 142-143, 2002

Improvement in complete response rate duration of response and survival with adriamycin combination chemo therapy for non hodgkins lymphoma a prognostic factor comparison of 2 regimens. Medical and Pediatric Oncology 4(4): 321-332, 1978

Increased Serum Carnitine Is an Adverse Prognostic Factor in Patients with Non-Hodgkins Lymphoma. Blood 100(11): Abstract No 4626, November 16, 2002

Prognostic significance of serum beta-2 microglobulin in patients with diffuse large B-cell lymphoma in the rituximab era. Oncotarget (): -, 2016

Beta-2 microglobulin as a significant prognostic factor and a new risk model for patients with diffuse large B-cell lymphoma. Hematological Oncology (): -, 2016

Prognostic Implication of the Absolute Lymphocyte to Absolute Monocyte Count Ratio in Patients With Classical Hodgkin Lymphoma Treated With Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine or Equivalent Regimens. Oncologist 21(3): 343-353, 2016

High serum beta-2-microglobulin levels are associated with human immunodeficiency virus-non-Hodgkins lymphoma. Blood 92(10 SUPPL 1 PART 1-2): 227B, Nov 15, 1998