+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome



Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome



Annual Review of Medicine 50: 531-545



Hantaviruses chronically infect rodents without apparent disease, but when they are spread by aerosolized excreta to humans, two major clinical syndromes result: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Both diseases appear to be immunopathologic, and inflammatory mediators are important in causing the clinical manifestations. In HPS, T cells act on heavily infected pulmonary endothelium, and it is suspected that gamma interferon and tumor necrosis factor are major agents of a reversible increase in vascular permeability that leads to severe, noncardiogenic pulmonary edema. HFRS has prominent systemic manifestations. The retroperitoneum is a major site of vascular leak and the kidneys suffer tubular necrosis. Both syndromes are accompanied by myocardial depression and hypotension or shock. HFRS is primarily a Eurasian disease, whereas HPS appears to be confined to the Americas; these geographic distinctions correlate with the phylogenies of the rodent hosts and the viruses that coevolved with them.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 035756903

Download citation: RISBibTeXText

PMID: 10073292

DOI: 10.1146/annurev.med.50.1.531


Related references

A novel Sin Nombre virus DNA vaccine and its inclusion in a candidate pan-hantavirus vaccine against hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). Vaccine 31(40): 4314-4321, 2014

A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome. Journal of Global Infectious Diseases 10(1): 22-25, 2018

Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?. Immunology Letters 113(2): 117-120, 2007

Immunopathogenesis of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Acta Medica Croatica 57(5): 407-414, 2004

Hemorrhagic fever with renal syndrome and coexisting hantavirus pulmonary syndrome. Kidney Research and Clinical Practice 31(2): 118-120, 2012

The Fifth International Conference on Hemorrhagic Fever with Renal Syndrome, Hantavirus Pulmonary Syndrome, and Hantaviruses. Emerging Infectious Diseases 8(1): 109, 2002

Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. Frontiers in Immunology 8: 567, 2017

Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained?. Virus Research 187: 55-58, 2015

Application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in IFA test: cross reactivities among 3 serotypes of hantavirus which causes hemorrhagic fever with renal syndrome (HFRS). Journal of Veterinary Medical Science 55(6): 1047-1050, 1993

Application of a Recombinant Baculovirus Expressing Hantavirus Nucleocapsid Protein as a Diagnostic Antigen in Ifa Test: Cross Reactivities among 3 Serotypes of Hantavirus which Causes Hemorrhagic Fever with Renal Syndrome(Hfrs). The Journal of Veterinary Medical Science 55(6): 1047-1050, 1993

Hantavirus pulmonary syndrome, renal insufficiency, and myositis associated with infection by Bayou hantavirus. Clinical Infectious Diseases 23(3): 495-500, 1996

Cross-neutralization of hantaviruses with immune sera from experimentally infected animals and from hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome patients. Journal of Infectious Diseases 172(6): 1581-1584, 1995

Hemorrhagic fever with renal syndrome: A case report of hantavirus infection. Journal of Microbiology Immunology & Infection 31(1): 64-68, 1998

Hemorrhagic fever with renal syndrome: first imported case of hantavirus infection in Taiwan. Journal of the Formosan Medical Association 95(6): 480-483, 1996

Mechanisms of disease in hantavirus infection: pathophysiology of hemorrhagic fever with renal syndrome. Reviews of Infectious Diseases 13(1): 97-107, 1991