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TYROSINE DEPLETION AUGMENTS HALOPERIDOL - INDUCED CATALEPSY AND ATTENUATES HALOPERIDOL - INDUCED DOPAMINE RELEASE IN THE STRIATUM OF THE RAT As MEASURED BY in vivo MICRODIALYSIS



TYROSINE DEPLETION AUGMENTS HALOPERIDOL - INDUCED CATALEPSY AND ATTENUATES HALOPERIDOL - INDUCED DOPAMINE RELEASE IN THE STRIATUM OF THE RAT As MEASURED BY in vivo MICRODIALYSIS



Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 536 3



In this series of studies we examined the effects of tyrosine depletion through administration of an amino acid mixture, on basal and haloperidol (HAL) -induced dopamine (DA) release in the striatum of the rat. Male Sprague-Dawley rats (225-275g) were pretreated with a tyrosine and phenylalanine free neutral amino acid mixture (NAA-) (1g/kg) administered in two IP injections 1 hr apart whereas other animals received a saline (SAL) vehicle. Rats then received HAL (0.19mg/kg SC). Catalepsy, measured on the bar test, was significantly increased in the NAA-group compared to the SAL group (p < 0.005). A different rat cohort had a unilateral cannula stereotaxically inserted into the striatum. Two days after surgery, a microdialysis probe (4.5 mm) was lowered to the coordinate (AP +1.2, ML + 3.2). Sixteen hrs later, microdialysate collection began (flow rate 1.0mul/min). Pretreatment with NAA-did not affect basal striatal DA release but significantly attenuated HAL-induced striatal DA release (p < 0.0001). These behavioral and neurochemical data suggest that haloperidol-induced striatal DA release is dependent on the availability of tyrosine. Accordingly, brain tyrosine levels could affect neuropsychiatric conditions and psychotropic drug actions.

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