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The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer

The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer

Medecine Sciences 19(10): 920-925

Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. Loss of heterozygosity at position 9q22.3 is one of the most frequent and is associated with highly recurrent tumours. The PATCHED gene, ortholog of a gene first described in the drosophila as a segment polarity gene, is located at 9q22.3. It is a member of a signal transduction pathway and a tumour suppressor gene (TSG), involved in basal cell carcinoma. We propose PATCHED as a TSG candidate in superficial bladder cancer.

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Accession: 035848683

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PMID: 14613000

DOI: 10.1051/medsci/20031910920

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